Recombinant CDKN2A Protein

• Description:

  Recombinant CDKN2A Protein_x000D_ Catalog number: B2017559_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 20 µg_x000D_ Molecular Weight or Concentration: 17.36 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Cyclin-dependent kinase inhibitor 2A, CDK4I, MTS-1, p16-INK4, p16INK4A_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Gong W, Zhao X, Tang X, Gao L, Sun Y, Ma J. Infectious Recombinant Senecavirus A Expressing p16(INK4A) Protein Int J Mol Sci. 2023 Mar 24;24(7):6139._x000D_ 2: Luo C, Zhou S, Zhou Z, Liu Y, Yang L, Liu J, Zhang Y, Li H, Liu Y, Hou FF, Zhou L. Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells J Am Soc Nephrol. 2018 Apr;29(4):1238-1256._x000D_ 3: Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Nat Cell Biol. 2009 Aug;11(8):973-9._x000D_ 4: Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T. A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition Sci Rep. 2014 Feb 6;4:4012._x000D_ 5: Abaandou L, Sharma AK, Shiloach J. Knockout of the caspase 8-associated protein 2 gene improves recombinant protein expression in HEK293 cells through up-regulation of the cyclin-dependent kinase inhibitor 2A gene Biotechnol Bioeng. 2021 Jan;118(1):186-198._x000D_ 6: Seavey CN, Hallett A, Li S, Che K, Pobbati AV, Ma S, Burtscher A, Kanai R, Lamar JM, Rubin BP. Loss of CDKN2A Cooperates with WWTR1(TAZ)-CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma Clin Cancer Res. 2023 Jul 5;29(13):2480-2493._x000D_ 7: Chen YH, Zhang X, Ko KY, Hsueh MF, Kraus VB. CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts Oxid Med Cell Longev. 2022 Feb 23;2022:5503575._x000D_ 8: Liu Y, Sharpless NE. Tumor suppressor mechanisms in immune aging Curr Opin Immunol. 2009 Aug;21(4):431-9._x000D_ 9: Zhao Q, Dong D, Chu H, Man L, Huang X, Yin L, Zhao D, Mu L, Gao C, Che J, Liu Q. lncRNA CDKN2A-AS1 facilitates tumorigenesis and progression of epithelial ovarian cancer via modulating the SOSTDC1-mediated BMP-SMAD signaling pathway Cell Cycle. 2021 Jun;20(12):1147-1162._x000D_ 10: Rahme GJ, Luikart BW, Cheng C, Israel MA. A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma Neuro Oncol. 2018 Feb 19;20(3):332-342. _x000D_ _x000D_ Products Related to Recombinant CDKN2A Protein can be found at Proteins

• Short Description:

  Catalog Number: B2017559 (20 µg)_x000D_ Recombinant CDKN2A protein is a laboratory-produced version of the CDKN2A protein, which is also known as p16 or p16INK4a. CDKN2A is a tumor suppressor protein that plays a key role in regulating cell cycle progression and preventing uncontrolled cell growth. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3