APC Anti-Mouse Foxp3 Antibody[3G3]

• Background:

  FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25) . Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.

• Abbreviation:

  Foxp3

• Gene ID:

  50943;20371;317382

• UniProt:

  Q99JB6

• Host:

  Mouse

• Reactivity:

  Mouse

• Target:

  Forkhead box protein P3; Foxp3; IPEX; JM2

• Clonality:

  Monoclonal

• Clone:

  3G3

• Conjugation:

  APC

• Applications:

  ICFCM

• Field of Research:

  Immunology

• Concentration:

  5 μL/Test

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Citation 01:

  https://link.springer.com/article/10.1186/s13046-025-03324-8

• Citation 02:

  https://www.science.org/doi/abs/10.1126/sciadv.adu1647

• Citation 03:

  https://www.sciencedirect.com/science/article/pii/S0168365925004080

• Citation 04:

  https://pmc.ncbi.nlm.nih.gov/articles/PMC12020135/

• Citation 05:

  https://www.sciencedirect.com/science/article/pii/S0168365923005461

• Citation 06:

  https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202301401

• Citation 07:

  https://www.sciencedirect.com/science/article/pii/S1742706124006329

• Citation 08:

  https://pubs.acs.org/doi/abs/10.1021/acsami.4c09925

• Citation 09:

  https://spj.science.org/doi/full/10.34133/bmr.0204

• Recommended Usage:

  The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

• Isotype:

  Mouse IgG1, κ