APC Anti-Mouse CD115/CSF-1R Antibody[AFS98]

• Background:

  CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

• Abbreviation:

  CD115

• Gene ID:

  12978

• UniProt:

  P09581

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  CD115; CSF-1 receptor (EC:2.7.10.1) ; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fms; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms

• Clonality:

  Monoclonal

• Clone:

  AFS98

• Conjugation:

  APC

• Applications:

  FCM

• Field of Research:

  Immunology

• Concentration:

  0.2 mg/mL

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Recommended Usage:

  6

• Isotype:

  Rat IgG2a, κ