PerCP Anti-Mouse CD8a Antibody[53-6.7]

• Background:

  CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

• Abbreviation:

  CD8a

• Gene ID:

  12525

• UniProt:

  P01731

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  CD8A; MAL; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2

• Clonality:

  Monoclonal

• Clone:

  53-6.7

• Conjugation:

  PerCP

• Applications:

  FCM

• Concentration:

  0.2 mg/mL

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Citation 01:

  https://www.nature.com/articles/s41419-022-05069-0

• Citation 02:

  https://www.nature.com/articles/s41419-023-06408-5

• Citation 03:

  https://link.springer.com/article/10.1007/s00262-024-03692-8

• Recommended Usage:

  6

• Isotype:

  Rat IgG2a, κ