APC Anti-Mouse CD86 Antibody[GL-1]

• Background:

  CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

• Abbreviation:

  CD86

• Gene ID:

  12524

• UniProt:

  P42082

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86

• Clonality:

  Monoclonal

• Clone:

  GL-1

• Conjugation:

  APC

• Applications:

  FCM

• Field of Research:

  Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

• Concentration:

  5 μL/Test

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Citation 01:

  https://www.sciencedirect.com/science/article/pii/S1748013223002864

• Citation 02:

  https://pubs.acs.org/doi/abs/10.1021/acsnano.3c04189

• Citation 03:

  https://www.nature.com/articles/s41467-023-40826-5

• Citation 04:

  https://www.sciencedirect.com/science/article/pii/S1385894723052051

• Citation 05:

  https://www.sciencedirect.com/science/article/pii/S138589472307002X

• Citation 06:

  https://www.sciencedirect.com/science/article/pii/S1385894723063775

• Citation 07:

  https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202207490

• Citation 08:

  https://pubs.acs.org/doi/abs/10.1021/acsnano.3c11848

• Citation 09:

  https://pubs.acs.org/doi/abs/10.1021/acsnano.4c07213

• Recommended Usage:

  The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

• Isotype:

  Rat IgG2a, κ