Mouse Cub Domain-Containing Protein 1, Cdcp1 Primacu™ ELISA Kit

Mouse Cub Domain-Containing Protein 1, Cdcp1 Primacu™ ELISA Kit

• Background: CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets.
• Description: CUB domain-containing protein 1
• Gene Name: Cdcp1
• Gene ID: 109332
• UniProt: Q5U462
• Origin Species: Mouse
• Reactivity: Mouse
• Target: CDCP1
• Field of Research: Cancer,Stem cells,Tags & cell markers
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 10 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 15.63-1000 pg/mL
• Sensitivity: 4.03 pg/mL
• Weight: 92726
• Storage Temperature: 2-8°C