Human Interleukin-1 Receptor Type 1, IL1R1 Primacu™ ELISA Kit

Human Interleukin-1 Receptor Type 1, IL1R1 Primacu™ ELISA Kit

• Background: Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
• Description: Interleukin-1 receptor type 1
• Synonyms: IL1R;IL1RA;IL1RT1
• Gene Name: IL1R1
• Gene ID: 3554
• UniProt: P14778
• Origin Species: Human
• Reactivity: Human
• Target: IL1R1
• Field of Research: Neuroscience,Cardiovascular,Immunology,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 30 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 46.88-3000 pg/mL
• Sensitivity: 16.86 pg/mL
• Weight: 65402
• Storage Temperature: 2-8°C