Human Granulocyte Colony-Stimulating Factor Receptor, CSF3R Primacu™ ELISA Kit

Human Granulocyte Colony-Stimulating Factor Receptor, CSF3R Primacu™ ELISA Kit

• Background: Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
• Description: Granulocyte colony-stimulating factor receptor
• Synonyms: GCSFR
• Gene Name: CSF3R
• Gene ID: 1441
• UniProt: Q99062
• Origin Species: Human
• Reactivity: Human
• Target: CSF3R
• Field of Research: Cancer,Immunology,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 32 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 50-3200 pg/mL
• Sensitivity: 11.34 pg/mL
• Weight: 92156
• Storage Temperature: 2-8°C