Human Interleukin-12 Subunit Beta, IL12B Primacu™ ELISA Kit

Human Interleukin-12 Subunit Beta, IL12B Primacu™ ELISA Kit

• Background: Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor-like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine is important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine that functions in innate and adaptive immunity.
• Description: Interleukin-12 subunit beta
• Synonyms: NKSF2
• Gene Name: IL12B
• Gene ID: 3593
• UniProt: P29460
• Origin Species: Human
• Reactivity: Human
• Target: IL12B
• Field of Research: Cancer,Immunology,Neuroscience
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 10 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 15.63-1000 pg/mL
• Sensitivity: 3.71 pg/mL
• Weight: 37169
• Storage Temperature: 2-8°C