Human Lysosome-Associated Membrane Glycoprotein 3, LAMP3 Primacu™ ELISA Kit

Human Lysosome-Associated Membrane Glycoprotein 3, LAMP3 Primacu™ ELISA Kit

• Background: Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in the activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.
• Description: Lysosome-associated membrane glycoprotein 3
• Synonyms: DCLAMP;TSC403
• Gene Name: LAMP3
• Gene ID: 27074
• UniProt: Q9UQV4
• Origin Species: Human
• Reactivity: Human
• Target: LAMP3
• Field of Research: Cancer,Stem cells,Tags & cell markers
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 20 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 31.25-2000 pg/mL
• Sensitivity: 7.55 pg/mL
• Weight: 44346
• Storage Temperature: 2-8°C