Human Granulocyte Colony-Stimulating Factor, CSF3 Primacu™ ELISA Kit

Human Granulocyte Colony-Stimulating Factor, CSF3 Primacu™ ELISA Kit

• Background: Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also revealed that G-CSF activates multiple signaling pathways, such as Akt and also the Janus family kinase-2 and signal transducer and activation of transcription-3 (Jak2-STAT3) pathway, thereby promoting survival, proliferation, differentiation and mobilisation of haematopoietic stem and progenitor cells. G-CSF is a cytokine that have been demonstrated to improve cardiac function and perfusion in myocardial infarction. And it was initially evaluated as a stem cell mobilizer and erythropoietin as a cytoprotective agent. G-CSF prevents left ventricular remodeling after myocardial infarction by decreasing cardiomyocyte death and by increasing the number of blood vessels, suggesting the importance of direct actions of G-CSF on the myocardium rather than through mobilization and differentiation of stem cells. Accordingly, recombinant human (rh)G-CSF has been extensively used in clinical haematology and oncology to enable bone marrow transplantation or to treat chemotherapy-associated neutropenia. In preclinical study, G-CSF improved cardiac function and perfusion by angiomyogenesis and protection of cardiomyocytes in myocardial infarction. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
• Description: Granulocyte colony-stimulating factor
• Synonyms: C17orf33;GCSF
• Gene Name: CSF3
• Gene ID: 1440
• UniProt: P09919
• Origin Species: Human
• Reactivity: Human
• Target: G-CSF
• Field of Research: Cancer,Immunology,Neuroscience
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 60 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 93.75-6000 pg/mL
• Sensitivity: 16.98 pg/mL
• Weight: 22293
• Storage Temperature: 2-8°C