Human Programmed Cell Death 1 Ligand 1, CD274 Primacu™ ELISA Kit

Human Programmed Cell Death 1 Ligand 1, CD274 Primacu™ ELISA Kit

• Background: Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. Cancer Immunotherapy Co-inhibitory Immune Checkpoint Targets Immune Checkpoint Immune Checkpoint Blockade: Blocking Antibodi Immune Checkpoint Blockade: PD-L1 / B7-H1 / C Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: WB Antibodies Immune Checkpoint Proteins Immune Checkpoint Targets Immunotherapy PD-L1 / B7-H1 / CD274 Immune Checkpoint Prote Targeted Therapy
• Description: Programmed cell death 1 ligand 1
• Synonyms: B7H1;PDCD1L1;PDCD1LG1;PDL1
• Gene Name: CD274
• Gene ID: 29126
• UniProt: Q9NZQ7
• Origin Species: Human
• Reactivity: Human
• Target: PD-L1
• Field of Research: Cancer,Immunology,Signal transduction
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 4 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 12.5-800 pg/mL
• Sensitivity: 3.26 pg/mL
• Weight: 33275
• Storage Temperature: 2-8°C