Human Cytotoxic T-Lymphocyte Protein 4, CTLA4 Primacu™ ELISA Kit

Human Cytotoxic T-Lymphocyte Protein 4, CTLA4 Primacu™ ELISA Kit

• Background: Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg). Cancer Immunotherapy Co-inhibitory Immune Checkpoint Targets CTLA4 / CD152 Immune Checkpoint Proteins Immune Checkpoint Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: WB Antibodies Immune Checkpoint Proteins Immune Checkpoint Targets Immunotherapy Targeted Therapy
• Description: Cytotoxic T-lymphocyte protein 4
• Synonyms: CD152
• Gene Name: CTLA4
• Gene ID: 1493
• UniProt: P16410
• Origin Species: Human
• Reactivity: Human
• Target: CTLA-4
• Field of Research: Immunology,Cancer
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 10 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 15.63-1000 pg/mL
• Sensitivity: 5.94 pg/mL
• Weight: 24656
• Storage Temperature: 2-8°C