Human Macrophage Colony-Stimulating Factor 1, CSF1 Primacu™ ELISA Kit

Human Macrophage Colony-Stimulating Factor 1, CSF1 Primacu™ ELISA Kit

• Background: Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
• Description: Macrophage colony-stimulating factor 1
• Gene Name: CSF1
• Gene ID: 1435
• UniProt: P09603
• Origin Species: Human
• Reactivity: Human
• Target: M-CSF
• Field of Research: Cardiovascular,Immunology,Neuroscience,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 15 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 23.44-1500 pg/mL
• Sensitivity: 9.41 pg/mL
• Weight: 60179
• Storage Temperature: 2-8°C