Human Interleukin-17 Receptor A, IL17RA Primacu™ ELISA Kit

Human Interleukin-17 Receptor A, IL17RA Primacu™ ELISA Kit

• Background: Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
• Description: Interleukin-17 receptor A
• Synonyms: IL17R
• Gene Name: IL17RA
• Gene ID: 23765
• UniProt: Q96F46
• Origin Species: Human
• Reactivity: Human
• Target: IL17RA
• Field of Research: Immunology
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 20 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 31.25-2000 pg/mL
• Sensitivity: 6.4 pg/mL
• Weight: 96122
• Storage Temperature: 2-8°C