AT7867 (dihydrochloride)

• UNSPSC Description:

  AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

• Target Antigen:

  Akt; PKA; Ribosomal S6 Kinase (RSK)

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AT7867-dihydrochloride.html

• Purity:

  99.75

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 2.27 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4.[H]Cl.[H]Cl

• Molecular Weight:

  410.77

• References & Citations:

  [1]Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9(5), 1100-1110.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1431697-86-7