C-10 (CCL6)

• Description:

  Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant murine C-10 is a 10.7 kDa protein containing 95 amino acid residues.

• Synonyms:

  Grcc10; PME; ULD; CST6; EPM1; STFB; EPM1A

• NCBI Gene ID:

  14790

• UniProt:

  O35127

• Accession Number:

  NP_038563.1

• Accession Number mRNA:

  NM_013535.1

• Chromosomal Location:

  6 F2; 6 60.22 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Bacteria

• Sequence:

  GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract Balb/c mouse spleen MNCs using a concentration range of 10-100 ng/ml.

• Length:

  95

• Form:

  Lyophilized

• Molecular Weight:

  10.7 kDa

• Host or Source:

  E. coli