Rabbit anti Human Calcium Channel
CAT:
579-X2712P
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rabbit anti Human Calcium Channel
- Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1b gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by omega-conotoxin-GVIA (omega-ctx-GVIA) and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to dihydropyridines (dhp), and omega-agatoxin-IVA (omega- aga-IVA). Calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
- Synonyms: Voltage-gated calcium channel subunit alpha Cav2.2, Calcium channel, L type, alpha-1 polypeptide isoform 5, Brain calcium channel III
- CAS Number: 9007-83-4
- UniProt: Q00975
- Host: Rabbit
- Species Reactivity: Human
- Isotype: IgG
- Conjugation: Affinity Purified
- Type: Antigen Immunoaffinity Purified Polyclonal
- Applications: WB
- Field of Research: Signal Transduction
- Purification Method: Antigen Immunoaffiinity Purification
- Assay Principle: Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.
- Stability: See expiration date on vial
- Concentration: See vial for Concentration
- Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
- Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
- References & Citations: 1. Dubel, S.J. et.al. 'Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel' Proc. Natl. Acad. Sci. U.S.A. 89 (11), 5058-5062 (1992) 2. Snutch,T.P.et.al. 'Rat brain expresses a heterogeneous family of calcium channels' Proc. Natl. Acad. Sci. U.S.A. 87 (9), 3391-3395 (1990) 3. Hell, J.W. et.al. 'Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini' J. Biol. Chem. 269 (10), 7390-7396 (1994) 4. Sunan, A.A. et.al. 'The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors.' J Neurosci. 21(19), 7587-97. (2001)
- Shipping Conditions: Ambient Temperature, freeze upon arrival
- Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
- Functional Analysis: WB