Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD16a (158V) Low Expression)

CAT:

716-CK-004-1Kit

Size:

1 Kit

Price:

Ask

For price, please contact [email protected]

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: Yes

Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD16a (158V) Low Expression)

Background: 4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.
Description: 4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.
CAS Number: 9007-83-4
Origin Species: Human
Target: 4-1BB & CD16a
Applications: Screen for Anti-human 4-1BB antibodies whether in a CD16a (158V)-dependent manner to strengthen the agonistic activity
Format: Solid
Shipping Conditions: Dry ice
Storage Conditions: Frozen in liquid nitrogen

Datasheet

Related Products

Cat	Name
CK-001-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD32a Low Expression)
CK-009-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD32b High Expression)
CK-011-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD64 Medium Expression)
CK-002-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD32a Medium Expression)
CK-012-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD64 High Expression)
CK-003-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD32a High Expression)
CK-007-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD32b Low Expression)
CK-008-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD32b Medium Expression)
CK-010-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human CD64 Low Expression)
CK-015-1Kit	Cell-based Screening Kit for Anti-human 4-1BB Antibody (Human PD-L1 High Expression)

Alternative Products

Cat	Name
79378	PD-1:PD-L2 Cell-Based Inhibitor Screening Assay Kit
79377	PD-1:PD-L1 Cell-Based Inhibitor Screening Assay Kit
60800	PD-1:PD-L1/PD-L2 Cell-Based Inhibitor Screening Assay Kit
NBP2-25086	TLR (Cell Surface) Screening Antibody Pack
72033	Human TDO Cell-Based Assay Kit
CB5843	ZNF24 Cell-Based ELISA
CB6082	ZNF397 Cell-Based ELISA
CB6089	ZNF596 Cell-Based ELISA
CB5764	TAF4 Cell-Based ELISA
CB5777	TRI18 Cell-Based ELISA