Penitrem A

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  Penitrem A is an indole-diterpenoid neurotoxic alkaloid produced by *Penicillium* species. As a selective BK channel antagonist, it exhibits antiproliferative and anti-invasive activities against various malignancies, and stimulates the spontaneous release of endogenous glutamate, GABA, and aspartate from cortical synaptosomes. It is commonly used to induce tremor models in animals.

• Smiles :

  [H][C@@]12O[C@]11[C@]([H])(CC[C@]3(C)[C@@]4(C)c5[nH]c6cc(Cl)c7CC(=C)[C@@]8([H])C[C@@]9([H])[C@@]8(O)c7c6c5[C@@]([H])(OC9(C)C)[C@]4([H])CC[C@@]13O)O[C@@H]([C@@H]2O)C(C)=C

• Molecular Formula :

  C37H44ClNO6

• Molecular Weight :

  634.2

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  12627-35-9