Z-Asp-CH2-DCB, Caspase inhibitor

• Catalog number
  SIH-206-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  153088-73-4
• Description
  Caspase inhibitor
• Molecular weight
  454,3 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  (3S)-3-{[(Benzyloxy)carbonyl]amino}-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C20H17Cl2NO7
• Origin
  Synthetic
• Purity pourcentage
  >99%
• Soluble in
  Soluble in methanol (50 mg/ml) or DMSO
• Physical appearance
  White to off-white Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  9911778
• Scientific context
  Irreversible, cell permeable broad-spectrum caspase inhibitor. Inhibits hypoxia-induced apoptosis in neuroblastoma cells.
• Release date
  16-May-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Z-Asp-CH2-DCB (SIH-206), a Caspase inhibitor. CAS #: 153088-73-4. Molecular Formula: C20H17Cl2NO7. Molecular Weight: 454.3 g/mol. Chemical structure of Z-Asp-CH2-DCB, a Caspase inhibitor (SIH-206). CAS # 153088-73-4. Molecular Formula: C20H17Cl2NO7.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Z-Asp-CH2-DCB   Caspase   inhibitor  
• Short name
  Z-Asp-CH2-DCB, Caspase inhibitor
• Alternative name
  Z-L-aspartic acid-CH2-DCB, caspase suppressor

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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