Recombinant Human ADAMTS5, (Aggrecanase2),truncated, His-tagged (Recombinant Protein)
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Catalog number
30 400 503
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Price
Please ask
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Size
100 µg/1000 µl
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Protein type
Recombinant
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Protein subtype
EC 3.4.24.14
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Protein family
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.
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Protein description
ADAMTS5 cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
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Research area interests
Diseases associated with ADAMTS5 include Osteoarthritis and Bone Inflammation Disease. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification
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Package form
liquid
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Tested applications
Degradation of extracellular matrix proteoglycans; screening and characterization of inhibitors; Standard in enzymatic and immunological assays
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Other names
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2); ADAM Metallopeptidase With Thrombospondin Type 1 Motif 6
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Peptide sequence
D625-930
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Available target modification
No
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Expression system
Insect Cell
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Product Subtype
protein fragment
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Active form
Yes
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Tag
His-tagged
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Contents
150 mM NaCl, 5 mM CaCl2, 50 mM imidazol, 50 mM Tris-HCl, pH 7.5, 0.05 % Brij-35 Detergent
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Protein purity
> 50 %
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Molecular weight
50 kDa
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UniProt number
Q9UNA0
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Gene number
11096
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Abbreviation
ADAMTS5 (partial)
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Full name
ADAM metallopeptidase with thrombospondin type 1 motif 5 (partial)
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Other desciption
Recombinant human ADAMTS5 Δ625-930 is produced with the baculovirus expression system and enriched from insect cell culture supernatants
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Purification
Mentioned in the data sheet
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PubMed citations
See the data sheet
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Warnings
For Research Use only.
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Shipping conditions
dry ice
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Storage condition
Store at -70°C
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Technical datasheet
Contact us to receive the datasheet
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ADAMTS5
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Short name
Recombinant ADAMTS5, (Aggrecanase2),truncated, His-tagged (Recombinant Protein)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Label
his-tagged
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Species
Homo sapiens, Humans
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Alternative name
Rec. H. sapiens ADAM metallopeptidase including thrombospondin classification 1 motif, 5, (Aggrecanase2),truncated, histidine-tagged (Rec. Protein)
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Alternative technique
rec
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Alternative to gene target
ADAM metallopeptidase with thrombospondin type 1 motif, 5, ADAM-TS 11 and ADAM-TS 5 and ADAM-TS5 and ADAMTS-11 and ADAMTS-5 and ADAMTS11 and ADMP-2, ADAMTS5 and IDBG-1207 and ENSG00000154736 and 11096, zinc ion binding, Extracellular, Adamts5 and IDBG-173252 and ENSMUSG00000022894 and 23794, ADAMTS5 and IDBG-630284 and ENSBTAG00000000648 and 286805
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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