p16-INK4a Recombinant Protein

• Catalog number
  40-118
• Price
  Please ask
• Size
  0.005 mg, 0.02 mg

• About recombinant protein
  p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. Recombinant p16-INK4a is a 16.5 kDa protein containing 156 amino acid residues.
• Other name of the recombinant
  ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A, Cyclin-dependent kinase 4 inhibitor A
• Recombinant in
  E. coli
• SEQUENCE
  MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD
• Keep at
  The lyophilized p16-INK4a recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted p16-INK4a is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing p16-INK4a recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4502749
• Accession nr
  NP_000068.1
• Pureity
  Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  1029
• Gene name
  cyclin-dependent kinase inhibitor 2A
• Source
  Homo sapiens
• Uniprot
  P42771
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  p16-INK4a   Protein  
• Gene symbol
  CDKN2A
• Short name
  p16-INK4a Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  p16-INK4a Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:23831
• Gene
  CDKN2A-DT
• Long gene name
  CDKN2A divergent transcript
• Synonyms gene
  • C9orf53
  • CDKN2A-AS1
• Synonyms gene name
  • chromosome 9 open reading frame 53
  • CDKN2A antisense RNA 1 (head to head)
• Synonyms
  • bA149I2.3
• GenBank acession
  • AF211119
• Locus
  9p21.3
• Discovery year
  2004-07-23
• Entrez gene record
  51198
• RefSeq identity
  • NR_024274
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000019687

Gene info

• Identity
  HGNC:1787
• Gene
  CDKN2A
• Long gene name
  cyclin dependent kinase inhibitor 2A
• Synonyms gene
  • CDKN2
  • MLM
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
• Synonyms
  • CDK4I
  • p16
  • INK4a
  • MTS1
  • CMM2
  • ARF
  • p19
  • p14
  • INK4
  • p16INK4a
  • p19Arf
  • p14ARF
• GenBank acession
  • L27211
• Locus
  9p21.3
• Discovery year
  1994-05-19
• Entrez gene record
  1029
• Pubmed identfication
  • 8152487
  • 7606716
• RefSeq identity
  • NM_000077
• VEGA ID
  OTTHUMG00000019686
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_11

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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