MMP 24 (MT5-MMP) catalytic domain, His-tagged (Recombinant Protein)

  • Catalog number
    30 100 903
  • Price
    Please ask
  • Size
    200 µg/ 1 ml
  • Protein type
    Recombinant
  • Protein subtype
    EC 3.4.24.80
  • Protein family
    Matrix Metalloproteinases, matrixins
  • Protein description
    MMP24 is a metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
  • Research area interests
    Among MMP24 related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix.
  • Package form
    liquid
  • Tested applications
    Activation of progelatinase A; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
  • Other names
    Membrane-Type 5 Matrix Metalloproteinase
  • Peptide sequence
    Y A L T G Q K W R Q K H I T Y S I H N Y T P K V G E L D T R K A I R Q A F D V W Q K V T P L T F E E V P Y H E I K S D R K E A D I M I F F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N A N H D G N D L F L V A V H E L G H A L G L E H S S D P S A I M A P F Y Q Y M E T H N F K L P Q D D L Q G I Q K I Y G P P A E P L E P T R P L P T L P V R R I H S P S V T H H H H H H
  • Available target modification
    No
  • Expression system
    E.coli
  • Product Subtype
    protein fragment
  • Active form
    Yes
  • Tag
    His-tagged
  • Contents
    50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2.
  • Protein purity
    > 90 %
  • Molecular weight
    22 kDa
  • UniProt number
    Q9Y5R2
  • Gene number
    10893
  • Abbreviation
    MMP24 (partial)
  • Full name
    matrix metallopeptidase 24 (partial)
  • Other desciption
    The catalytic domain of human MT5-MMP is produced by activation of a recombinant soluble proform of MT5-MMP purified from E. coli periplasm.
  • Purification
    Mentioned in the data sheet
  • PubMed citations
    See the data sheet
  • Warnings
    For Research Use only.
  • Shipping conditions
    dry ice
  • Storage condition
    Store at -70°C
  • Technical datasheet
    Contact us to receive the datasheet
  • Conjugation
    histidine
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    MMP24, MMP14, MMP28, MMP17, MMP15, MMP25, MMP16
  • Short name
    MMP 24 (MT5-MMP) catalytic domain, His-tagged (Recombinant Protein)
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Label
    his-tagged
  • Species
    Homo sapiens
  • Alternative name
    MMP 24 (MT5-MMP) catalytic domain, histidine-tagged (Rec. Protein)
  • Alternative technique
    rec
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    matrix metallopeptidase 17
  • Synonyms gene name
    • matrix metalloproteinase 17 (membrane-inserted)
    • matrix metallopeptidase 17 (membrane-inserted)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-11-13
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • M10 matrix metallopeptidases
  • VEGA ID
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    matrix metallopeptidase 16
  • Synonyms gene
  • Synonyms gene name
    • matrix metalloproteinase 16 (membrane-inserted)
    • chromosome 8 open reading frame 57
    • matrix metallopeptidase 16 (membrane-inserted)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-11-13
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • M10 matrix metallopeptidases
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products
Filters
Contact
Chat with gentaur.com employee