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Stock availabilitIn Stock
In Stock
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CAS number
404-86-4
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Description
TRPV1opener
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Molecular weight
305,41 g/mol
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Primary research fields
Neuroscience, Ion Channels, Transient Receptor Potential Channels
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Other name
(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C18H27NO3
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in 100% ethanol, methanol or chloroform; Sparingly soluble in water
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Physical appearance
Off-White Solid
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Storage recommendations
-20ÂșC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes Risk Phrases: R25-37/38-41-42/43 Hazard Phrases: H301-H311-H315-H317-H318-H334-H335 Precautionary Phrases: P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
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PubChem number
1548943
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Scientific context
Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).
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Bibliography
1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824. 2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333. 3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Capsaicin (SIH-322), a TRPV1opener. CAS #: 404-86-4. Molecular Formula: C18H27NO3. Molecular Weight: 305.41 g/mol. Chemical structure of Capsaicin, a TRPV1opener (SIH-322). CAS # 404-86-4. Molecular Formula: C18H27NO3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.2
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