C3a Receptor (mouse) - Polyclonal
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Catalog number
T-2301.0100
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Price
Please ask
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Size
100ug
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Synonym
Complement C3a Anaphylatoxin Receptor, C3aR
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StorageTemperature
+5 ± 3 °C
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HOST
Chicken
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Clone
N/A
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Format
Purified, Liquid
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Species Crossreactivity
mouse
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Application
IHC
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Conjugate
NA
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Top Categories
Antibodies
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Keywords
Polyclonal; primary antibody
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Additonal Description
The complement C3a anaphylatoxin receptor (C3aR) is a seven-transmembrane G-protein coupled chemoattractant receptor that mediates numerous cellular responses. The second of the three extracellular loops is unusually large and seems to play a role in agonist binding. C3aR can be detected at various levels in practically all tissues. Inflammation seems to strongly increase the expression of C3aR. In human bacterial meningitis, strong expression of C3aR was observed on astrocytes, microglia, and infiltrating macrophages and neutrophils. The antibody was generated against the cytoplasmic carboxy-terminal portion of the mouse C3aR. Application: IHC (f)
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
C3AR1
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Short name
C3a Receptor (mouse) - Polyclonal
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Technique
Polyclonal, Mouse, mouses, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Host
mouse
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Isotype
IgY
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Species
Mouse, Mouses
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Alternative name
C3a Receptor (mouse) - polyclonal
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Alternative technique
polyclonals, murine
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Gene info
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