NSJ Bioreagents

NSJ Bioreagents is a biotechnology company based in San Diego, California, specializing in the development and supply of high-quality antibodies and research reagents. Founded in 2014, the company leverages over 20 years of experience in antibody production to serve the life science community .

Product Portfolio

NSJ Bioreagents offers a diverse range of products tailored for various research applications:

Monoclonal and Polyclonal Antibodies: These antibodies are designed for use in cancer research, tumor biomarkers, apoptosis studies, immunology, cell biology, transcription factors, and epigenetics .
Recombinant Monoclonal Antibodies: Produced with defined nucleic acid sequences, these antibodies ensure superior lot-to-lot consistency, eliminating issues like hybridoma drift or loss .
Human Protein Microarray Validated Antibodies: Tested against over 19,000 proteins, these antibodies offer high specificity for various targets .
Isotype Controls and Loading Controls: Essential for accurate flow cytometry and immunohistochemistry experiments.

Browse NSJ Bioreagents Products

10-Formyltetrahydrofolate dehydrogenase Antibody / ALDH1L1

SKU: V5388-100UG|Size: 100 µg

12 Lipoxygenase Antibody / ALOX12

SKU: R30558|Size: 100 µg

14-3-3 Sigma Antibody

SKU: V3999SAF-100UG|Size: 100 µg

14-3-3 epsilon Antibody / YWHAE

SKU: V7362-20UG|Size: 20 µg

14-3-3 gamma Antibody / YWHAG

SKU: RQ5931|Size: 100 µg

14-3-3 sigma Antibody

SKU: R33530-100UG|Size: 100 µg

14-3-3 sigma Antibody (Biotin Conjugate)

SKU: R33530BTN|Size: 100 µg

14-3-3 theta Antibody

SKU: R33403-100UG|Size: 100 µg

14-3-3 zeta/delta Antibody / YWHAZ

SKU: RQ4280|Size: 100 µg

15-PGDH Antibody / HPGD

SKU: R33680-100UG|Size: 100 µg

17-beta-HSD 13 Antibody / HSD17B13

SKU: V5741SAF-100UG|Size: 100 µg

17-beta-HSD 3 Antibody / HSD17B3

SKU: RQ7344|Size: 100 µg

17-beta-Hydroxysteroid dehydrogenase 4 Antibody (HSD17B4)

SKU: R30817|Size: 100 µg

17-beta-hydroxysteroid dehydrogenase 13 Antibody / HSD17B13

SKU: V5744SAF-100UG|Size: 100 µg

17HSD7 Antibody / HSD17B7

SKU: RQ7371|Size: 100 µg

3BP2 Antibody / SH3 domain-binding protein 2 / SH3BP2

SKU: RQ8165|Size: 100 µg

4-1BBL Antibody / CD137L / TNSF9

SKU: RQ7455|Size: 100 µg

4-Alpha-glucanotransferase Antibody / AGL / Glycogen debranching enzyme

SKU: RQ8505|Size: 100 µg

40S Ribosomal protein SA Antibody / RPSA / Laminin Receptor 1

SKU: V9408-100UG|Size: 100 µg

40S ribosomal protein S14 Antibody / RPS14

SKU: RQ7951|Size: 100 µg

4E-T Antibody / EIF4ENIF1

SKU: RQ7948|Size: 100 µg

5-HT2C Receptor Antibody / HTR2C

SKU: RQ7304|Size: 100 µg

5-HT3C Antibody / 5-hydroxytryptamine receptor 3C / HTR3C

SKU: RQ8700|Size: 100 µg

5-Lipoxygenase Antibody

SKU: R30133|Size: 100 µg

5-Lipoxygenase Antibody / ALOX5

SKU: RQ5292|Size: 100 µL

53BP1 Antibody / Tumor Protein p53-Binding Protein 1

SKU: R31082|Size: 100 µg

58K Golgi protein Antibody

SKU: RQ4820|Size: 100 µL

58K Golgi protein Antibody / Golgi Marker

SKU: V9383SAF-100UG|Size: 100 µg

58K Golgi protein Antibody / Golgi Marker Biotin Conjugate

SKU: R36023BTN|Size: 100 µg

5HT1A Receptor Antibody

SKU: R30731|Size: 100 µg

5HT1B Antibody / HTR1B

SKU: RQ6562|Size: 100 µg

5HT2A Receptor Antibody

SKU: R30442|Size: 100 µg

5HT2AR Antibody

SKU: R32043|Size: 100 µg

5HT2B Receptor Antibody

SKU: R32094|Size: 100 µg

5HT3B receptor Antibody

SKU: R35996-100UG|Size: 100 µg

60 kDa Heat Shock Protein Antibody / Hsp60

SKU: F54512-0.2ML|Size: 0.2 mL

A-Raf Antibody / ARAF

SKU: RQ5320|Size: 100 µL

A1BG Antibody

SKU: F50307-0.08ML|Size: 0.08 mL

A20 Antibody / TNFAIP3

SKU: V8384-20UG|Size: 20 µg

A2M Antibody / Alpha-2-Macroglobulin

SKU: V4246-100UG|Size: 100 µg

A2M Antibody / Alpha-2-macroglobulin

SKU: F44166-0.4ML|Size: 0.4 mL

A2ML1 Antibody

SKU: F48844-0.08ML|Size: 0.08 mL

A4GALT Antibody

SKU: F40481-0.4ML|Size: 0.4 mL

A4GNT Antibody

SKU: R35144-100UG|Size: 100 µg

AAAS Antibody / Adracalin

SKU: F53900-0.2ML|Size: 0.2 mL

AACS Antibody

SKU: F53144-0.4ML|Size: 0.4 mL

AACT Antibody / Alpha-1-Antichymotrypsin / SERPINA3

SKU: V9447-100UG|Size: 100 µg

AADAC Antibody

SKU: F49883-0.4ML|Size: 0.4 mL

AADACL1 Antibody / Arylacetamide deacetylase-like 1 / NCEH1

SKU: RQ8227|Size: 100 µg

AADAT Antibody

SKU: R34561-100UG|Size: 100 µg

AADC Antibody / DOPA Decarboxylase / DDC

SKU: F54418-0.4ML|Size: 0.4 mL

AAK1 Antibody

SKU: R34135-100UG|Size: 100 µg

AAMP Antibody / Angio associated migratory cell protein

SKU: R31545|Size: 100 µg

AANAT Antibody

SKU: F51822-0.08ML|Size: 0.08 mL

AARS2 Antibody

SKU: F40154-0.08ML|Size: 0.08 mL

AARSD1 Antibody

SKU: R34332-100UG|Size: 100 µg

AASS Antibody / LKR / SDH

SKU: RQ6595|Size: 100 µg

AAT Antibody / Alpha 1 Antitrypsin / SERPINA1

SKU: V4338-100UG|Size: 100 µg

AATF Antibody / Apoptosis-antagonizing transcription factor

SKU: FY13151|Size: 100 µg

AATK Antibody

SKU: F43913-0.08ML|Size: 0.08 mL

ABAT Antibody / 4-Aminobutyrate aminotransferase

SKU: R32487|Size: 100 µg

ABCA2 Antibody

SKU: F53014-0.08ML|Size: 0.08 mL

ABCA4 Antibody

SKU: R31176|Size: 100 µg

ABCA4 Antibody / ATP-binding cassette sub-family A member 4

SKU: R36498-100UG|Size: 100 µg

ABCA9 Antibody

SKU: R35449-100UG|Size: 100 µg

ABCB1 Antibody / ATP-binding cassette sub-family B member 1 / P-glycoprotein / MDR1

SKU: V5208-100UG|Size: 100 µg

ABCB1 Antibody / P Glycoprotein / MDR1

SKU: RQ6755|Size: 100 µg

ABCB10 Antibody

SKU: R32456|Size: 100 µg

ABCB11 Antibody

SKU: F49436-0.4ML|Size: 0.4 mL

ABCB4 Antibody

SKU: F49438-0.08ML|Size: 0.08 mL

ABCB4 Antibody / MDR3

SKU: R31688|Size: 100 µg

ABCB5 Antibody

SKU: R35491-100UG|Size: 100 µg

ABCB6 Antibody

SKU: R30813|Size: 100 µg

ABCB7 Antibody

SKU: F49439-0.08ML|Size: 0.08 mL

ABCB9 Antibody

SKU: R34095-100UG|Size: 100 µg

ABCC1 Antibody / MRP1

SKU: R34260-100UG|Size: 100 µg

ABCC10 Antibody

SKU: F40497-0.4ML|Size: 0.4 mL

ABCC11 Antibody

SKU: F48871-0.08ML|Size: 0.08 mL

ABCC3 Antibody

SKU: F40498-0.08ML|Size: 0.08 mL

ABCC4 Antibody / ATP-binding cassette sub-family C member 4 / MRP4

SKU: V5380-20UG|Size: 20 µg

ABCC4 Antibody / MRP4

SKU: V5381SAF-100UG|Size: 100 µg

ABCC5 Antibody

SKU: R34373-100UG|Size: 100 µg

ABCC5 Antibody / MRP5

SKU: RQ5789|Size: 100 µg

ABCC8 Antibody / SUR1

SKU: R33765-100UG|Size: 100 µg

ABCC9 Antibody

SKU: F46433-0.4ML|Size: 0.4 mL

ABCD1 Antibody

SKU: F40661-0.08ML|Size: 0.08 mL

ABCD1 Antibody / ATP-binding cassette sub-family D member 1

SKU: FY12269|Size: 100 µL

ABCD2 Antibody

SKU: F42334-0.08ML|Size: 0.08 mL

ABCD3 Antibody

SKU: R34973-100UG|Size: 100 µg

ABCD3 Antibody Biotin Conjugate

SKU: R34973BTN|Size: 100 µg

ABCD4 Antibody

SKU: R35553-100UG|Size: 100 µg

ABCE1 Antibody

SKU: R34523-100UG|Size: 100 µg

ABCE1 Antibody / ATP-binding cassette sub-family E member 1

SKU: FY12915|Size: 100 µg

ABCF1 Antibody

SKU: F51628-0.4ML|Size: 0.4 mL

ABCF2 Antibody

SKU: F45139-0.08ML|Size: 0.08 mL

ABCG1 Antibody

SKU: F49667-0.08ML|Size: 0.08 mL

ABCG2 Antibody

SKU: F44284-0.4ML|Size: 0.4 mL

ABCG2 Antibody (BCRP)

SKU: R30969|Size: 100 µg

ABCG4 Antibody

SKU: F42410-0.08ML|Size: 0.08 mL

ABCG5 Antibody

SKU: R32320|Size: 100 µg

Recent Breakthroughs

AI-Driven Chemometrics for Multi-omics Data Integration: Advances, Challenges, and Future Directions.

Polu PR.

Crit Rev Anal Chem

PMID:42010462

Free PMC article

The convergence of artificial intelligence and chemometrics has revolutionized multi-omics data integration, enabling unprecedented insights into complex biological systems. This critical review examines AI-driven approaches for integrating genomics, proteomics, metabolomics, and other omics layers, emphasizing developments from 2020 to 2025. We explore fundamental multi-omics challenges including batch effects, high dimensionality, and structural heterogeneity, evaluating how classical chemometric methods have evolved into sophisticated deep learning architectures. Convolutional neural networks, autoencoders, variational autoencoders, and graph neural networks demonstrate remarkable capabilities for non-linear feature extraction and data fusion. Explainable AI frameworks including SHAP and LIME address interpretability concerns critical for analytical chemistry. We review vertical and horizontal integration strategies, highlighting transformer-based attention mechanisms and biological network-informed architectures. Clinical applications in Alzheimer's disease, obesity, and cancer demonstrate 20%-30% performance improvements over traditional approaches. Emerging hyphenated techniques coupling microfluidics with mass spectrometry enable miniaturized analyses. Persistent challenges include computational scalability, overfitting mitigation, regulatory validation gaps, and interdisciplinary collaboration barriers. Future directions encompass federated learning for privacy-preserving analyses, quantum computing applications, and single-cell spatial multi-omics at subcellular resolution. This assessment provides analytical chemists with critical evaluation of available tools, benchmarking strategies, and roadmaps for advancing precision medicine and analytical applications.

Nucleic acid aptamer-functionalized magnetic MIL-53(Al)-NH<sub>2</sub> for highly selective magnetic dispersion solid-phase extraction of chloramphenicol.

Peng L, Yao Y, Li M, Ji X, Cao J, Zhang J, Zhong F, Yang X, Hu X.

Analyst

PMID:41801140

Free PMC article

Chloramphenicol (CAP), a broad-spectrum antibiotic banned in food animals due to its toxic effects ( e.g. , myelosuppression), requires sensitive analytical methods for the detection and monitoring of its residues in food. Herein, an aptamer-functionalized magnetic MOF composite (CAP-Apt@MMIL-53(Al)-NH 2 ) was prepared, coupled with a HPLC method developed for CAP detection. The material was synthesized as follows: solvothermally prepared Fe 3 O 4 particles were coated with SiO 2 , modified with mercaptoacetic acid, and self-assembled with Al 3+ and 2-aminoterephthalic acid to form MMIL-53(Al)-NH 2 . Its porous framework and abundant amino sites enable efficient mass transfer and aptamer immobilization. CAP aptamers were then covalently bonded to its surface amino sites, yielding CAP-Apt@MMIL-53(Al)-NH 2 with high selectivity. Notably, the material reaches extraction equilibrium within 5 minutes, with 2.2-fold higher efficiency than MMIL-53(Al)-NH 2 and 2.5-5.8-fold higher efficiency than traditional adsorbents, and exhibits significantly reduced post-extraction chromatographic interference. The analytical method exhibited a linear range of 10-1000 μg L -1 ( R 2 = 0.998) and an LOD of 4.89 μg L -1 . Applied to milk and honey, it yielded recoveries of 84.3%-110.1% and 88.0%-118.0%, respectively. This approach enables rapid, selective, and sensitive detection of trace CAP in complex food matrices, providing a novel strategy for food safety monitoring of CAP residues.

Proliferation-associated protein 2G4 promotes keratinocyte proliferation and survival in psoriasis.

Raunegger T, Wasserer S, Eigemann J, Hillig C, Aydin G, Kurzen N, Schmidt-Weber CB, Menden MP, Garzorz-Stark N, Weßels I, Eyerich S, Eyerich K, Biedermann T, Lauffer F, Jargosch M.

Br J Dermatol

PMID:42008715

Free PMC article

Background Psoriasis is a non-communicable inflammatory skin disease that affects approximately 2%-3% of the world's population. Given its high impact on quality of life and the fact that a subset of patients exhibits suboptimal or secondary loss of response to current treatments, identifying new therapeutic strategies is crucial. Proliferation-associated protein 2G4 (PA2G4) is a transcription factor that has been exclusively studied in cancer research, where it promotes cell growth and enhances tumourigenesis by inhibiting apoptosis. However, its role in inflammatory skin diseases remains largely unknown. Objectives This study focused on the pathophysiological and immunological functions of PA2G4 in psoriasis and evaluated its potential as a therapeutic target. Methods Bulk, single-cell, and spatial RNA sequencing combined with immunohistochemistry were used to assess PA2G4 expression in psoriatic skin compared with that in non-lesional controls. Functional studies were performed in primary human keratinocytes and reconstructed human epidermis (RHE) models using the CRISPR/Cas9-mediated knockout (KO) of PA2G4 and pharmacological inhibition of PA2G4 with the small-molecule WS6. The regulatory effects of PA2G4 on cellular processes, such as proliferation, differentiation, and survival, were investigated using RNA-seq, western blot analysis, scratch assays, and annexin V staining. Results PA2G4 was highly abundant in psoriasis, and its expression was predominantly restricted to basal proliferating keratinocytes. Its gene expression is positively correlated with psoriasis severity, the degree of acanthosis, neutrophil infiltration, and genes which are upregulated in psoriasis. PA2G4 KO in primary human keratinocytes activated differentiation pathways while suppressing proliferation pathways, resulting in the downregulation of proliferation- and inflammation-related genes (e.g. MKI67, IL20, VEGFA, and HIF1A) and the upregulation of differentiation and cell adhesion markers (e.g. KRT6C, LCE2C, and DSG4). Functionally, the PA2G4 KO reduced keratinocyte proliferation in scratch assays, attenuated interleukin-22-induced acanthosis in RHE models, and promoted keratinocyte death. Pharmacological inhibition of PA2G4 using the small-molecule inhibitor WS6 similarly downregulated genes associated with proliferation and cell survival. Conclusions PA2G4 could promote keratinocyte hyperproliferation and survival in psoriasis, thereby critically influencing epidermal homeostasis. Therefore, inhibition of PA2G4 may represent a new treatment option for psoriasis.