RAGE, Rat/Mouse, Receptor for Advanced Glycation End Products
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Catalog numberRAGE002
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Price:
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Size100 mcg
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CloneNA
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Species ReactivityRat, mouse, others not tested
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Product TypesPrimary Antibodies
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Positive ControlDiabetic retina or renal tissue
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ImmunogenThe immunizing peptide corresponds to amino acid residues 362-380 from rat RAGE, Synthetic Peptide: C(362) W R K R Q P R (R/L) E E R K A P E S Q E D(NH2)(380). This sequence is 100% conserved in mouse and 70% conserved in humans.
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Working Concentration(liquid conc.) 1-5 µg/ml IHC, 1-2 µg/ml WB
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Concentration1 mg/ml
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Incubation Time60 min at RT or 18 hr at 2-8°C
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ApplicationIHC(C), WB
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Storage-20°C
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UniProtNA
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus, Rattus norvegicus
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolAGER, MOK
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Short nameRAGE, /Mouse, Receptor for Advanced Glycation End Products
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TechniqueMouse, mouses
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HostRabbit
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IsotypeNA
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SpeciesMouse, Mouses, Rats
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Alternative nameRAGE, Rat/Mouse, Receptor to measure Advanced Glycation End Products
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Alternative techniquemurine
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Gene info
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Identity
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Gene
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Long gene nameadvanced glycosylation end-product specific receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-10-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Scavenger receptors
- C2-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMOK protein kinase
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Synonyms gene
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Synonyms gene name
- renal tumor antigen
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-05-10
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Entrez gene record
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Pubmed identfication
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VEGA ID