RAGE, Rat/Mouse, Receptor for Advanced Glycation End Products
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Catalog number
RAGE002
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Price
Please ask
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Size
100 mcg
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Clone
NA
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Species Reactivity
Rat, mouse, others not tested
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Product Types
Primary Antibodies
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Positive Control
Diabetic retina or renal tissue
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Immunogen
The immunizing peptide corresponds to amino acid residues 362-380 from rat RAGE, Synthetic Peptide: C(362) W R K R Q P R (R/L) E E R K A P E S Q E D(NH2)(380). This sequence is 100% conserved in mouse and 70% conserved in humans.
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Working Concentration
(liquid conc.) 1-5 µg/ml IHC, 1-2 µg/ml WB
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Concentration
1 mg/ml
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Incubation Time
60 min at RT or 18 hr at 2-8°C
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Application
IHC(C), WB
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Storage
-20°C
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UniProt
NA
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus, Rattus norvegicus
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
AGER, MOK
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Short name
RAGE, /Mouse, Receptor for Advanced Glycation End Products
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Technique
Mouse, mouses
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Host
Rabbit
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Isotype
NA
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Species
Mouse, Mouses, Rats
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Alternative name
RAGE, Rat/Mouse, Receptor to measure Advanced Glycation End Products
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Alternative technique
murine
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Gene info
Gene info
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Identity
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Gene
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Long gene name
MOK protein kinase
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Synonyms gene
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Synonyms gene name
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Synonyms
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GenBank acession
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Locus
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Discovery year
1995-05-10
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Entrez gene record
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Pubmed identfication
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VEGA ID
Product images
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