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Navinci Diagnostics is a Swedish biotechnology company specializing in advanced spatial proteomics solutions. Founded in 2004 as Olink Bioscience, the company rebranded to Navinci Diagnostics in 2016. Navinci is renowned for its proprietary Naveni® in situ proximity ligation technology, which enables the detection and quantification of protein interactions and post-translational modifications within their native cellular environments .
Navinci's Naveni® technology utilizes a novel approach to proximity ligation, enhancing the sensitivity and specificity of protein detection. This method involves the use of Navenibodies—antibodies conjugated to proprietary oligonucleotide arms—that bind to primary antibodies targeting specific proteins. When these Navenibodies are in close proximity, the oligonucleotides can form a circular DNA structure, serving as a template for rolling circle amplification (RCA). The amplified DNA product is then detected as brightly fluorescent spots, allowing for precise localization and quantification of protein interactions at the single-molecule level .
Navinci Diagnostics provides a range of products based on its Naveni® technology:
