Integrin alpha Chains

MeSH code information

• Name
  Integrin alpha Chains
• Concept
  Scope note: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
• Tree numbers
  • D12.776.543.750.705.408.100
• Qualifiers
  isolation & purification, immunology, biosynthesis, physiology, therapeutic use, agonists, blood, deficiency, chemistry, drug effects, radiation effects, history, analysis, classification, genetics, administration & dosage, antagonists & inhibitors, ultrastructure, metabolism