Heavy Chain Disease

MeSH code information
  • Name
  • Concept
    Scope note:A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
  • Tree numbers
    • C15.378.147.780.490
    • C15.604.515.435
    • C20.683.780.490
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