Human Microphthalmia-associated transcription factor (MITF) -E. coli

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• Catalog number
  GEN1236019.E.coli
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• Size
  1000ug

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• Long name
  Recombinant Human Microphthalmia-associated transcription factor (MITF)
• Alternative names
  microphthalmia-associated transcription factor isoform 4; Microphthalmia-associated transcription factor; microphthalmia-associated transcription factor; class E basic helix-loop-helix protein 32; microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32
• Gene name
  MITF
• Other gene names
  MITF; MITF; MI; WS2; CMM8; WS2A; bHLHe32; BHLHE32; bHLHe32
• General description
  Microphthalmia-associated transcription factor (MITF) is a recombinant protein expressed in E. coli. The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.
• Product category
  Recombinant Proteins
• Expression system
  E. coli
• Available also expressed in
  E Coli ; Yeast ; Baculovirus ; Mammalian Cell
• Purity
  Greater than 90% (determined by SDS-PAGE)
• Form
  Lyophilized protein
• Storage
  This protein can be stored at -20 degrees Celsius. For extended periods of time it is recommended to keep the protein frozen at -40 or -80 degrees Celsius. Avoid cycles of freezing and thawing as they might denaturate the polypeptide chains.
• Applications
  This protein can be used as a positive control for applications such as ELISA, IFA, RIA, Western Blot, etc.
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

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• Gene target
  Microphthalmia-associated   transcription   factor   MITF  
• Gene symbol
  MITF
• Short name
  Microphthalmia-associated transcription factor (MITF)
• Host
  e. coli, Escherichia coli, Recombination of bioactive proteins and longer peptides in Escherichia Coli is done often with His tagging. MBS Recombinant supplies Rec. E. Coli affinity purified or tag purified antigens in 1 quantities or bulk volumes on request.
• Species
  E. coli, E. coli, Humans
• Alternative name
  H. sapiens Microphthalmia-associated transcription factor (microphthalmia-associated transcription factor) -E. coli
• Alternative technique
  escherichia
• Alternative to gene target
  microphthalmia-associated transcription factor, bHLHe32 and CMM8 and MI and WS2 and WS2A, MITF and IDBG-44086 and ENSG00000187098 and 4286, protein dimerization activity, nuclei, Mitf and IDBG-172461 and ENSMUSG00000035158 and 17342, BT.29882 and IDBG-644985 and ENSBTAG00000006679 and 407219

Gene info

• Identity
  HGNC:7105
• Gene
  MITF
• Long gene name
  melanocyte inducing transcription factor
• Synonyms gene
  • WS2A
  • WS2
• Synonyms gene name
  • Waardenburg syndrome, type 2A
  • microphthalmia-associated transcription factor
  • melanogenesis associated transcription factor
• Synonyms
  • MI
  • bHLHe32
• Synonyms name
  • homolog of mouse microphthalmia
• Locus
  3p13
• Discovery year
  1993-10-27
• Entrez gene record
  4286
• Pubmed identfication
  • 8069297
  • 7874167
  • 7951321
• RefSeq identity
  • NM_198159
• Classification
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000149921
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_776

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