Oncostatin M Protein
- Catalog numberOPPB00185
- Product nameOncostatin M Protein
- Sizeone vial
- StorageFor short term storage Oncostatin M Protein may be kep at +4 deg. C. For long term storage keep the aliquoted vials frozen at -20 degrees Celsius.
- TipsDue to handling and transportation, small amounts of the Oncostatin M Protein may get caught on the walls or seal of the vials. Prior to use briefly rund the vial(s) through a centrifuge to collect all of the content on the bottom. Avoid freezing and thawing the vials numerous times as such cycles may denaturate the peptide chains and influence the item's performance.
- Gene target
- Short nameOncostatin M Protein
- Alternative nameOncostatin M Protein
- ConceptRegistry number:106956-32-5Scope note:A cytokine with both pro- and anti-inflammatory actions that depend upon the cellular microenvironment. Oncostatin M is a 28 kDa monomeric glycoprotein that is similar in structure to LEUKEMIA INHIBITORY FACTOR. Its name derives from the the observation that it inhibited the growth of tumor cells and augmented the growth of normal fibroblasts.CASN1 number:Oncostatin M
- Tree numbers
- Qualifiersimmunology, pharmacokinetics, biosynthesis, physiology, therapeutic use, secretion, toxicity, poisoning, administration & dosage, adverse effects, agonists, blood, cerebrospinal fluid, chemical synthesis, contraindications, deficiency, chemistry, drug effects, urine, radiation effects, history, analysis, antagonists & inhibitors, classification, economics, genetics, isolation & purification, metabolism, pharmacology, standards, supply & distribution, ultrastructure
- PubMedsOSMR is able to bind OSM and interleukin-31 when associated to soluble gp130 or soluble interleukin-31R, respectively, and to neutralize both cytokine propertiesFPLCA has been mapped to 5p13.1-q11.2, and by candidate gene analysis, study identified missense mutations in the OSMR gene, encoding oncostatin M-specific receptor beta (OSMRbeta), in three families.murine OSMR initiates STAT5 activation directly via the receptor bound Janus kinases. Intriguingly, the murine receptor preferentially recruits JAK2, whereas the human receptor seems to have a higher affinity for JAK1.Two new pathogenic heterozygous missense mutations in the OSMR gene (p.Val631Leu and p.Asp647Tyr) were identified in two Dutch familial primary localized cutaneous amyloidosis families.A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.
- Entrez Gene
- Gene ontology - Cellular component
- Gene ontology - Biological process
- Gene ontology - Molecular function