MMP 9/ Lipocalin Complex (Native Protein)
Matrix Metalloproteinases, matrixins
MMP9 may play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Research area interests
Diseases associated with MMP9 include Metaphyseal Anadysplasia 2 and Metaphyseal Anadysplasia. Among its related pathways are Pathways in cancer and Integrin Pathway.
Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Available target modification
Yes, after Trypsin activation
50 mM Tris-HCl, pH 7.0, 200 mM NaCl, 5 mM CaCl2, 1 μM ZnCl2, 0.05 % Brij-35, 0.05 % NaN3
The 92 kDa and the 220 kDa represent the monomer and the disulfide-bridged homodimer of Progelatinase B. The 130 kDa form could be identified as a disulfide bridge complex of the monomer and a 25 kDa protein which belongs to the lipocalin family
Progelatinase B complex is isolated from human blood.
Mentioned in the data sheet
See the data sheet
For Research Use only.
Store at -70°C
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