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Ebselen, Protein Kinase C inhibitor

  • Catalog number
    SIH-204-10MG
  • Product name
    Ebselen, Protein Kinase C inhibitor
  • Size
    10 mg
  • Price
    111.71 USD
  • Supplier
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    60940-34-3
  • Description
    Protein Kinase C inhibitor
  • Molecular weight
    274,18 g/mol
  • Primary research fields
    Cancer, Apoptosis
  • Other name
    2-Phenyl-1,2-benzoselenazol-3(2H)-one
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C13H9NOSe
  • Origin
    Synthetic
  • Purity pourcentage
    >99%
  • Soluble in
    Soluble in DMSO and 100% ethanol
  • Physical appearance
    Off-white Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Harmful: May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: 23/25-33-50/53 Hazard Phrases: H301-H331-H373-H410 Precautionary Phrases: P261-P273-P301 + P310-P311-P501
  • PubChem number
    3194
  • Scientific context
    Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
  • Bibliography
    1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169. 2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619. 3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17. 4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.
  • Release date
    16-May-2011
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Ebselen (SIH-204), a Glutathione peroxidase mimic. CAS #: 60940-34-3. Molecular Formula: C13H9NOSe. Molecular Weight: 274.18 g/mol. Chemical structure of Ebselen, a Glutathione peroxidase mimic (SIH-204). CAS # 60940-34-3. Molecular Formula: C13H9NOSe.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight (kg)
    0.25
  • Net weight (g)
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Ebselen, Protein Kinase C inhibitor
  • Alternative name
    Ebselen, Protein phosphorylation catalyst C suppressor
Additional information
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