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Cycloheximide for cell activation

  • Catalog number
    1041-5G
  • Product name
    Cycloheximide for cell activation
  • Size
    5 g
  • Price
    273EUR
  • Supplier
    Biovision
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  • Description
    A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.
  • Peptide sequence
    N/A
  • CAS number
    66-81-9
  • Molecular weight
    281.35
  • Category
    Apoptosis Inducer
  • Other name
    3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
  • Molecular formula
    C₁₅H₂₃NO₄
  • Physical appearance
    Off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    >95%
  • Reconstitute instructions
    DMSO or EtOH
  • Storage condition
    -20°C
  • Shipping condition
    RT
  • Maximum time for storage
    12 months
  • Storage instructions
    Protect from light and moisture
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    Cycloheximide for activation
  • Technique
    activation
  • Alternative name
    Cycloheximide to measure cellular activation
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MESH Data
  • Name
  • Concept
    Registry number: 98600C0908
    Scope note: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
    CASN1 number: 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-
  • Tree numbers
    • D03.383.621.808.240
  • Qualifiers
    analogs & derivatives, immunology, pharmacokinetics, biosynthesis, therapeutic use, toxicity, poisoning, administration & dosage, adverse effects, agonists, blood, cerebrospinal fluid, chemical synthesis, contraindications, chemistry, urine, radiation effects, history, analysis, antagonists & inhibitors, classification, economics, isolation & purification, metabolism, pharmacology, standards, supply & distribution
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