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RCAN2 Isoform 2 Recombinant Protein

  • Catalog number
    95-114
  • Product name
    RCAN2 Isoform 2 Recombinant Protein
  • Size
    0.05 mg
  • Price
    382.17
  • Supplier
    proscience
  • About recombinant protein
    Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).
  • Other name of the recombinant
    RCAN2 Antibody: Csp2, MCIP2, ZAKI-4, Dscr1l1, Zaki4, Calcipressin-2, Calcineurin inhibitory protein ZAKI-4
  • Recombinant in
    E. coli
  • His tag on the recombinant protein
    Fusion Partner: C-terminal His-tag
  • SEQUENCE
    aa 2 - 197
  • Activity
    not available
  • Use of recmbinant
    This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
  • Protein is used in
    E, WB, MS
  • Suspention medium
    100mM sodium phosphate, 10mM Tris, 500mM NaCl, 25 mM imidazole, 2mM MgCl2, 10% gycerol
  • Keep at
    Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec. PROTEIN GI#
    38328420
  • Accession nr
    AAH62141
  • KDa of reombinant
    26 kDa (Calculated)
  • Pureity
    ~95%
  • About
    Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
  • Protein's origin
    Mouse
  • Vial
    Liquid
  • NCBI ID
    53901
  • Gene name
    regulator of calcineurin 2
  • Source
    Mus musculus
  • Uniprot
    Q9JHG2
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    Rcan2
  • Short name
    RCAN2 Isoform 2 Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    RCAN2 Isoform 2 recombinant Protein
  • Alternative technique
    rec
1. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
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