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DR6 Cytoplasmic Domain Recombinant Protein

  • Catalog number
    95-119
  • Product name
    DR6 Cytoplasmic Domain Recombinant Protein
  • Size
    0.05 mg
  • Price
    382.17
  • Supplier
    proscience
  • About recombinant protein
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3). The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
  • Other name of the recombinant
    DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
  • Recombinant in
    E. coli
  • His tag on the recombinant protein
    Fusion Partner: C-terminal His-tag
  • SEQUENCE
    aa 371 - 655
  • Activity
    not available
  • Use of recmbinant
    This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
  • Protein is used in
    E, WB, MS
  • Suspention medium
    1X PBS containing 10% glycerol
  • Keep at
    Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec. PROTEIN GI#
    7657039
  • Accession nr
    NP_055267
  • KDa of reombinant
    36 kDa (Calculated)
  • Pureity
    ~95%
  • About
    Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
  • Protein's origin
    Mouse
  • Vial
    Liquid
  • NCBI ID
    27242
  • Gene name
    tumor necrosis factor receptor superfamily, member 21
  • Source
    Homo sapiens
  • Uniprot
    O75509
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    TNFRSF21
  • Short name
    DR6 Cytoplasmic Domain Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    DR6 Cytoplasmic Domain recombinant Protein
  • Alternative technique
    rec
1. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
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