DR6 Cytoplasmic Domain Recombinant Protein

• Catalog number
  95-119
• Price
  Please ask
• Size
  0.05 mg

• About recombinant protein
  Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3). The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
• Other name of the recombinant
  DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
• Recombinant in
  E. coli
• His tag on the recombinant protein
  Fusion Partner: C-terminal His-tag
• SEQUENCE
  aa 371 - 655
• Activity
  not available
• Use of recmbinant
  This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
• Protein is used in
  E, WB, MS
• Suspention medium
  1X PBS containing 10% glycerol
• Keep at
  Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  7657039
• Accession nr
  NP_055267
• KDa of reombinant
  36 kDa (Calculated)
• Pureity
  ~95%
• About
  Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
• Protein s origin
  Mouse
• Vial
  Liquid
• NCBI ID
  27242
• Gene name
  tumor necrosis factor receptor superfamily, member 21
• Source
  Homo sapiens
• Uniprot
  O75509
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  DR6   Cytoplasmic   Domain   Protein  
• Gene symbol
  TNFRSF21
• Short name
  DR6 Cytoplasmic Domain Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  DR6 Cytoplasmic Domain Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:13469
• Gene
  TNFRSF21
• Long gene name
  TNF receptor superfamily member 21
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 21
• Synonyms
  • DR6
  • CD358
• Synonyms name
  • death receptor 6
• GenBank acession
  • AF068868
• Locus
  6p12.3
• Discovery year
  2001-07-27
• Entrez gene record
  27242
• Pubmed identfication
  • 9714541
• RefSeq identity
  • NM_014452
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000014796

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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