Eukaryotic Leptin Receptor (LEPR)

• Catalog number
  EPA083Hu61
• Price
  Please ask
• Size
  100ug

• Source
  Eukaryotic expression
• Predicted Molecular Mass KD
  95.1kDa
• Accurate Molecular Mass KD
  95kDa
• Organism species
  Homo sapiens (Human)
• Item Name
  Leptin Receptor
• Alternative Names
  CD295; LEPR; OBR; LR
• Research Area
  Signal transduction;CD & Adhesion molecule;Metabolic pathway;Endocrinology;
• Buffer Formulation
  20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
• Traits
  Freeze-dried powder
• Isoelectric Point
  7.2
• Purity
  > 98%
• Protein length
  Phe22~Asp839
• Tag
  N-terminal His Tag
• Expression System
  Eukaryotic expression
• Application
  Positive Control; Immunogen; SDS-PAGE; WB.
• Manual link
• Gene
  Human or mouse Leptin (from Greek λεπτός leptos, "thin") the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. ELISA kits and peptides and antibodies are available.
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Eukaryotic   Leptin   Receptor   LEPR  
• Gene symbol
  LEPR
• Short name
  Eukaryotic Leptin Receptor (LEPR)
• Host
  293F cell
• Species
  Homo sapiens (Human)
• Alternative name
  Eukaryotic Leptin Receptor (leptin receptor)
• Alternative to gene target
  leptin receptor, CD295 and LEP-R and LEPRD and OB-R and OBR, LEPR and IDBG-99469 and ENSG00000116678 and 3953, identical protein binding, Extracellular, Lepr and IDBG-167734 and ENSMUSG00000057722 and 16847, LEPR and IDBG-638266 and ENSBTAG00000005910 and 497205,785813

Gene info

• Identity
  HGNC:6554
• Gene
  LEPR
• Long gene name
  leptin receptor
• Synonyms
  • OBR
  • CD295
• GenBank acession
  • U43168
• Locus
  1p31.3
• Discovery year
  1996-05-09
• Entrez gene record
  3953
• Pubmed identfication
  • 8548812
  • 8812446
• RefSeq identity
  • NM_002303
• Classification
  • CD molecules
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000009115
• Locus Specific Databases
  • LRG_283

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