Eukaryotic Leptin Receptor (LEPR)
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Catalog number
EPA083Hu61
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Price
Please ask
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Size
100ug
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Source
Eukaryotic expression
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Predicted Molecular Mass KD
95.1kDa
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Accurate Molecular Mass KD
95kDa
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Organism species
Homo sapiens (Human)
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Item Name
Leptin Receptor
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Alternative Names
CD295; LEPR; OBR; LR
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Research Area
Signal transduction;CD & Adhesion molecule;Metabolic pathway;Endocrinology;
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Buffer Formulation
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
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Traits
Freeze-dried powder
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Isoelectric Point
7.2
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Purity
> 98%
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Protein length
Phe22~Asp839
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Tag
N-terminal His Tag
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Expression System
Eukaryotic expression
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Application
Positive Control; Immunogen; SDS-PAGE; WB.
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Gene
Human or mouse Leptin (from Greek λεπτός leptos, "thin") the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. ELISA kits and peptides and antibodies are available.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
LEPR
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Short name
Eukaryotic Leptin Receptor (LEPR)
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Host
293F cell
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Species
Homo sapiens (Human)
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Alternative name
Eukaryotic Leptin Receptor (leptin receptor)
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Alternative to gene target
leptin receptor, CD295 and LEP-R and LEPRD and OB-R and OBR, LEPR and IDBG-99469 and ENSG00000116678 and 3953, identical protein binding, Extracellular, Lepr and IDBG-167734 and ENSMUSG00000057722 and 16847, LEPR and IDBG-638266 and ENSBTAG00000005910 and 497205,785813
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Gene info
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Identity
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Gene
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Long gene name
leptin receptor
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Synonyms
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GenBank acession
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Locus
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Discovery year
1996-05-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Immunoglobulin like domain containing
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VEGA ID
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Locus Specific Databases
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