JE (MCP-1), murine recombinant

Catalog number

4207-1000
Price

Please ask
Size

1 mg

Synonyms

Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine (C-C motif) ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11, Immediate-early serum-responsive JE protein.
Alternative_names

Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine (C-C motif) ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11, Immediate-early serum-responsive JE protein.
Description

Chemoattractant for monocytes and basophils
Recombinant

Yes
Source

E. coli
Purity by SDS PAGE

≥98%
Assay

SDS-PAGE
Purity

≥98%
Biological activity

Determined by measuring the dose dependent chemotaxis with human THP-1 cells. The ED₅₀ is in the range of 1-10 ng/ml
Results

1-10 ng/ml
Molecular Weight

13.8 kDa
Storage Temp

-20°C
Shipping

Gel pack
Shelf Life

12 months
Appearance

Lyophilized protein
Physical form description

Sterile filtered and lyophilized with no additives
Reconstitution Instructions

Reconstitute in H₂O to a concentration of 0.1-1 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.
Background Information

Murine JE (also known as Macrophage/Monocyte Chemotactic Protein) is a 13.8 kDa protein containing 125 amino acid residues. It plays an important role in the inflammatory response of blood monocytes and tissue microphages.
Handling

Centrifuge the vial prior to opening.
Usage

For Research Use Only! Not to be used in humans
Datasheet
Additional source

Recombinants or rec. proteins
Group

recombinants

Gene target

MCP-1 murine
Gene symbol

CCL2, CAPG, CCL13, CCL8, SLC25A33, CD46, CCR2, CCL7, IGHVII-1-1, MIR1-1
Short name

JE (MCP-1), murine recombinant
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Alternative name

JE (MCP-1), murine Rec.
Alternative technique

rec

Gene info

Identity

HGNC:10618
Gene

CCL2
Long gene name

C-C motif chemokine ligand 2
Synonyms gene
- SCYA2
Synonyms gene name
- small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
- chemokine (C-C motif) ligand 2
Synonyms
- MCP1
- MCP-1
- MCAF
- SMC-CF
- GDCF-2
- HC11
- MGC9434
Synonyms name
GenBank acession
- BC009716
Locus

17q12
Discovery year

1990-07-05
Entrez gene record

6347
Pubmed identfication
- 2004761
RefSeq identity
- NM_002982
Classification
- Chemokine ligands
VEGA ID

OTTHUMG00000132887

Gene info

Identity

HGNC:1474
Gene

CAPG
Long gene name

capping actin protein, gelsolin like
Synonyms gene
- AFCP
Synonyms gene name
- capping protein (actin filament), gelsolin-like
Synonyms
- MCP
Synonyms name
- macrophage capping protein
GenBank acession
- M94345
Locus

2p11.2
Discovery year

1993-12-14
Entrez gene record

822
Pubmed identfication
- 1322908
- 12754261
RefSeq identity
- NM_001747
Classification
- Gelsolin/villins
VEGA ID

OTTHUMG00000130183

Gene info

Identity

HGNC:10611
Gene

CCL13
Long gene name

C-C motif chemokine ligand 13
Synonyms gene
- SCYA13
Synonyms gene name
- small inducible cytokine subfamily A (Cys-Cys), member 13
- chemokine (C-C motif) ligand 13
Synonyms
- MCP-4
- NCC-1
- SCYL1
- CKb10
- MGC17134
GenBank acession
- AJ001634
Locus

17q12
Discovery year

1997-02-11
Entrez gene record

6357
Pubmed identfication
- 8661057
RefSeq identity
- NM_005408
Classification
- Chemokine ligands
VEGA ID

OTTHUMG00000132890

Gene info

Identity

HGNC:10635
Gene

CCL8
Long gene name

C-C motif chemokine ligand 8
Synonyms gene
- SCYA8
Synonyms gene name
- small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
- chemokine (C-C motif) ligand 8
Synonyms
- MCP-2
- HC14
GenBank acession
- X99886
Locus

17q12
Discovery year

1996-11-14
Entrez gene record

6355
Pubmed identfication
- 9119400
RefSeq identity
- NM_005623
Classification
- Chemokine ligands
VEGA ID

OTTHUMG00000132883

Gene info

Identity

HGNC:29681
Gene

SLC25A33
Long gene name

solute carrier family 25 member 33
Synonyms gene name
- solute carrier family 25, member 33
- solute carrier family 25 (pyrimidine nucleotide carrier), member 33
Synonyms
- MGC4399
- BMSC-MCP
- PNC1
GenBank acession
- AF495714
Locus

1p36.22
Discovery year

2006-09-21
Entrez gene record

84275
Pubmed identfication
- 14715278
- 16949250
RefSeq identity
- NM_032315
Classification
- Solute carriers
VEGA ID

OTTHUMG00000001322

Gene info

Identity

HGNC:6953
Gene

CD46
Long gene name

CD46 molecule
Synonyms gene
- MIC10
- MCP
Synonyms gene name
- antigen identified by monoclonal antibody TRA-2-10
- membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
- CD46 antigen, complement regulatory protein
- CD46 molecule, complement regulatory protein
Synonyms
- TRA2.10
- MGC26544
- TLX
GenBank acession
- BC030594
Locus

1q32.2
Discovery year

1988-08-31
Entrez gene record

4179
Pubmed identfication
- 7929741
RefSeq identity
- NM_172361
Classification
- Sushi domain containing
- Complement system regulators and receptors
- CD molecules
VEGA ID

OTTHUMG00000036397
Locus Specific Databases
- LRG_155

Gene info

Identity

HGNC:1603
Gene

CCR2
Long gene name

C-C motif chemokine receptor 2
Synonyms gene
- CMKBR2
Synonyms gene name
- chemokine (C-C motif) receptor 2
Synonyms
- CC-CKR-2
- CKR2
- MCP-1-R
- CD192
- FLJ78302
Locus

3p21.31
Discovery year

1995-05-30
Entrez gene record

729230
Pubmed identfication
- 8146186
RefSeq identity
- NM_000647
Classification
- C-C motif chemokine receptors
- CD molecules
VEGA ID

OTTHUMG00000156466

Gene info

Identity

HGNC:10634
Gene

CCL7
Long gene name

C-C motif chemokine ligand 7
Synonyms gene
- SCYA6
- SCYA7
Synonyms gene name
- small inducible cytokine A7 (monocyte chemotactic protein 3)
- chemokine (C-C motif) ligand 7
Synonyms
- MCP-3
- NC28
- FIC
- MARC
- MCP3
Synonyms name
- monocyte chemoattractant protein 3
- monocyte chemotactic protein 3
GenBank acession
- AF043338
Locus

17q12
Discovery year

1993-11-04
Entrez gene record

6354
Pubmed identfication
- 8461011
RefSeq identity
- NM_006273
Classification
- Chemokine ligands
VEGA ID

OTTHUMG00000132889

Gene info

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Gene info

Identity

HGNC:31499
Gene

MIR1-1
Long gene name

microRNA 1-1
Synonyms gene
- MIRN1-1
Synonyms
- hsa-mir-1-1
Locus

20q13.33
Discovery year

2004-04-23
Entrez gene record

406904
RefSeq identity
- NR_029780
Classification
- MicroRNA MIR1/206 family

MeSH Data

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

JE (MCP-1), murine recombinant

Gene info

Gene info

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MeSH Data

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