Human CellExp™ Lipocalin-2 / LCN2, rat recombinant

  • Catalog number
  • Supplier
  • Price
    1217.49 USD
  • Size
    50 ug
  • Synonyms
    NGAL, LCN2, Lipocalin-2, 24p3, MSFI, Siderocalin; Oncogene 24p3; Neutrophil Gelatinase-associated Lipocalin; NGAL.
  • Alternative_names
    NGAL, LCN2, Lipocalin-2, 24p3, MSFI, Siderocalin; Oncogene 24p3; Neutrophil Gelatinase-associated Lipocalin; NGAL.
  • Description
    Functions as a growth factor and is upregulated during inflammation
  • Recombinant
  • Source
    HEK293 cells
  • Purity by SDS PAGE
  • Assay
  • Molecular Weight
    ~25.0 kDa (monomer). Rat lipocalin-2 (aa 1-198) is fused at the C-terminus to a FLAG®-tag.
  • Storage Temp
  • Shipping
    Gel Pack
  • Shelf Life
    6 months
  • Appearance
  • Physical form description
    0.2 um-filtered solution in PBS
  • Background Information
    Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • About
    Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
  • Latin name
    Rattus norvegicus
  • Additional source
    Recombinants or rec. proteins
  • Group
  • Gene target
  • Gene symbol
  • Short name
    CellExp™ Lipocalin-2 / LCN2, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Host
  • Species
    Humans, Rats
  • Alternative name
    H. sapiens CellExp™ Lipocalin-2 / lipocalin 2, rat Rec.
  • Alternative technique
  • Alternative to gene target
    lipocalin 2, 24p3 and MSFI and NGAL, LCN2 and IDBG-87415 and ENSG00000148346 and 3934, protein homodimerization activity, Extracellular, Lcn2 and IDBG-160059 and ENSMUSG00000026822 and 16819, BT.61865 and IDBG-639105 and ENSBTAG00000014149 and 526639
Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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Human CellExp Lipocalin 2 LCN2 rat recombinant -
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