Human CellExp™ FOLR1, Fc Tag, Human Recombinant

  • Catalog number
  • Price
    Please ask
  • Size
    10 ug
  • Synonyms
    FOLR1, FBP, FOLR, FOLR-1, Folate-receptor-alpha
  • Alternative_names
    FOLR1, FBP, FOLR, FOLR-1, Folate-receptor-alpha
  • Description
    Mediates delivery of 5-methyltetrahydrofolate to the interior of cells
  • Recombinant
  • Source
    HEK293 cells
  • Purity by SDS PAGE
  • Assay
  • Endotoxin Level
    < 1.0 EU per/ug
  • Activity Specifications test method
    Measured by its binding ability in a functional ELISA.
  • Biological activity
    Immobilized Folic acid-BSA conjugate at 5 ug/mL (100 uL/well) can bind Human FOLR1, Fc Tag with a linear range of 10-78 ng/mL
  • Binding Capacity
    Immobilized Folic acid-BSA conjugate at 5 ug/mL (100 uL/well) can bind Human FOLR1, Fc Tag with a linear range of 10-78 ng/mL
  • Molecular Weight
    51.3 kDa
  • Storage Temp
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
  • Reconstitution Instructions
    Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
  • Background Information
    Folate Receptor 1 (FOLR1) also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
  • Gene target
    CellExp™   FOLR1   Tag  
  • Gene symbol
  • Short name
    CellExp™ FOLR1, Fc Tag, Recombinant
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Label
    Fc Tag
  • Species
  • Alternative name
    H. sapiens CellExp™ folate receptor 1 (adult), fragment c detection labelled, H. sapiens Rec.
  • Alternative technique
  • Alternative to gene target
    folate receptor 1 (adult), FBP and FOLR, FOLR1 and IDBG-63244 and ENSG00000110195 and 2348, folic acid transporter activity, Plasma membranes, Folr1 and IDBG-202269 and ENSMUSG00000001827 and 14275
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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