CXCL4, human recombinant

• Catalog number
  7346-20
• Price
  Please ask
• Size
  20 ug

• Synonyms
  Chemokine (C-X-C motif) ligand 4, PF4, MGC138298, SCYB4
• Alternative_names
  Chemokine (C-X-C motif) ligand 4, PF4, MGC138298, SCYB4
• Description
  Functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥85%
• Assay
  SDS-PAGE
• Molecular Weight
  10.0 kDa (91 aa, 32-101 aa + His Tag), confirmed by MALDI-TOF.
• Storage Temp
  -80°C
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Concentration
  0.25 mg/ml
• Appearance
  Liquid
• Physical form description
  0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 2 mM DTT and 50% glycerol.
• Background Information
  CXCL4 is a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. Recombinant human CXCL4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MEAEEDGDLQ CLCVKTTSQV RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQAPL YKKIIKKLLE S
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CXCL4  
• Gene symbol
  PF4
• Short name
  CXCL4, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  CXCL4, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:8861
• Gene
  PF4
• Long gene name
  platelet factor 4
• Synonyms
  • SCYB4
  • CXCL4
• Synonyms name
  • chemokine (C-X-C motif) ligand 4
• GenBank acession
  • M25897
• Locus
  4q13.3
• Discovery year
  2001-06-22
• Entrez gene record
  5196
• Pubmed identfication
  • 3622011
• VEGA ID
  OTTHUMG00000130009
• Locus Specific Databases
  • LRG_636

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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