B7-H4 /VTCN1, mouse recombinant

  • Catalog number
    P1107-10
  • Supplier
  • Price
    143.51 USD
  • Size
    10 ug
  • Synonyms
    V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1
  • Alternative_names
    V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1
  • Description
    Negatively regulates T-cell-mediated immune response and is involved in promoting epithelial cell transformation
  • Recombinant
    Yes
  • Source
    CHO cells
  • Purity by SDS PAGE
    ≥98%
  • Assay
    SDS-PAGE
  • Endotoxin Level
    < 0.06 EU/ug
  • Activity Specifications test method
    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells
  • Biological activity
    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells
  • Storage Temp
    -20°C
  • Shipping
    Gel pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.2 um-filtered solution in PBS
  • Reconstitution Instructions
    Reconstitute with 100 µl sterile water.
  • Background Information
    B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    VTCN1, H4C6, HHLA2, H4C13, RNY4P2, LRRC23, H4C8, PCDHGB7, NCR3LG1, CD274
  • Short name
    B7-H4 /VTCN1, mouse recombinant
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Host
    mouse
  • Species
    Mouse, Mouses
  • Alternative name
    B7-H4 /V-set domain containing T cellular activation inhibitor 1, mouse Rec.
  • Alternative technique
    rec, murine
  • Alternative to gene target
    V-set domain containing T cell activation inhibitor 1, VTCN1 and IDBG-101440 and ENSG00000134258 and 79679, protein binding, Cell surfaces, Vtcn1 and IDBG-179327 and ENSMUSG00000051076 and 242122, VTCN1 and IDBG-634392 and ENSBTAG00000014466 and 539919
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    RNY4 pseudogene 2
  • Synonyms gene name
    • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
    • RNA, Ro-associated Y4 pseudogene 2
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-25
  • Entrez gene record
  • RefSeq identity
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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B7 H4 VTCN1 mouse recombinant - Gentaur.com
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