Anti-CoV-2 & SARS-CoV S1 Antibody (Clone# CR3022)

• Catalog number
  A2103-200
• Price
  Please ask
• Size
  200 µg

• Antibody Target
  CoV-2 & SARS-CoV Spike S1
• Target Alternative Name
  PRSS10; Transmembrane protease serine 2; Serine protease 10, PP9284, Serine protease 10 antibody, TMPRSS2, TMPS2
• Antibody Type
  Monoclonal
• Clone
  CR3022
• Species Reactivities
  Rat,Mouse,Human
• Immunogen Sequence
  This antibody binds the amino acids 300-500 in the S1 domain of the SARS-CoV as well as SARS-CoV-2 Spike protein. The binding epitope is only accessible in the "open" conformation of the spike protein
• Accession
  P59594
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS with 0.02% Proclin 300
• Purification
  Protein A affinity purified
• Application
  Immunohistochemistry (IHC),Western Blotting
• Application And Usages
  WB 1:500 - 1:2000, IHC 1:50 - 1:200
• Description
  Coronaviruses (CoV) are a large group of enveloped positive-sense RNA viruses. They belong to subfamily Coronavirinae, in the family of Coronaviridae, of the order of Nidovirales. The Coronavirus genome is about 30 kb in length and encodes four structural proteins, namely, spike (S), envelope (E), membrane (M) and nucleocapsid (N), multiple nonstructural proteins and other accessory proteins. The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: S1 domain whose main function is receptor binding, and S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of host for attachment during the viral entry, this induces conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CoV-2   SARS-CoV   CR3022  
• Gene symbol
  SARS1, SARS2
• Short name
  Anti-CoV-2 & SARS-CoV S1 Antibody (Clone# CR3022)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG1, kappa
• Alternative name
  Antibody toCoV-2 & SARS-CoV S1 (antibody to-) (clonality# CR3022)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10537
• Gene
  SARS1
• Long gene name
  seryl-tRNA synthetase 1
• Synonyms gene
  • SARS
• Synonyms gene name
  • seryl-tRNA synthetase
• Synonyms
  • SERS
• Synonyms name
  • serine tRNA ligase 1, cytoplasmic
• GenBank acession
  • BC009390
• Locus
  1p13.3
• Discovery year
  1995-06-09
• Entrez gene record
  6301
• Pubmed identfication
  • 9431993
• RefSeq identity
  • NM_006513
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000011726

Gene info

• Identity
  HGNC:17697
• Gene
  SARS2
• Long gene name
  seryl-tRNA synthetase 2, mitochondrial
• Synonyms gene
  • SARSM
• Synonyms gene name
  • serine-tRNA ligase, mitochondrial
  • seryl-tRNA synthetase 2
• Synonyms
  • FLJ20450
  • mtSerRS
  • SerRSmt
  • SARS
  • SERS
  • SYS
• Synonyms name
  • serine tRNA ligase 2, mitochondrial
• GenBank acession
  • AB029948
• Locus
  19q13.2
• Discovery year
  2002-10-09
• Entrez gene record
  54938
• Pubmed identfication
  • 10764807
• RefSeq identity
  • NM_017827
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000182691

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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