- Catalog numberA2103-200
- Product nameAnti-CoV-2 & SARS-CoV S1 Antibody (Clone# CR3022)
- Size200 µg
- PriceAsk For Price
- Antibody TargetCoV-2 & SARS-CoV Spike S1
- Target Alternative NamePRSS10; Transmembrane protease serine 2; Serine protease 10, PP9284, Serine protease 10 antibody, TMPRSS2, TMPS2
- Antibody TypeMonoclonal
- CloneCR3022
- IsotypeHuman IgG1, kappa
- Species ReactivitiesRat,Mouse,Human
- Immunogen SequenceThis antibody binds the amino acids 300-500 in the S1 domain of the SARS-CoV as well as SARS-CoV-2 Spike protein. The binding epitope is only accessible in the "open" conformation of the spike protein
- AccessionP59594
- AppearanceColorless liquid
- FormLiquid
- FormulationIn PBS with 0.02% Proclin 300
- PurificationProtein A affinity purified
- ApplicationImmunohistochemistry (IHC),Western Blotting
- Application And UsagesWB 1:500 - 1:2000, IHC 1:50 - 1:200
- DescriptionCoronaviruses (CoV) are a large group of enveloped positive-sense RNA viruses. They belong to subfamily Coronavirinae, in the family of Coronaviridae, of the order of Nidovirales. The Coronavirus genome is about 30 kb in length and encodes four structural proteins, namely, spike (S), envelope (E), membrane (M) and nucleocapsid (N), multiple nonstructural proteins and other accessory proteins. The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: S1 domain whose main function is receptor binding, and S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of host for attachment during the viral entry, this induces conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.
- Storage Condition-20ºC
- Shipping ConditionGel Pack
- Shelf Life12 months
- UsageFor Research Use Only! Not to be used in humans.
- HandlingThe antibody solution should be gently mixed before use.
- Western Blot Verified0
- Immunocytochemistry Verified0
- Immunofluorescence Verified0
- Immunoprecipitation Verified0
- FACS Verified0
- ELISA Verified0
- ChIP Verified0
- Dot Blot Verified0
- Flow Cytometry Verified0
- Data Sheet Link
- Gene targetCoV-2 SARS-CoV S1 CR3022
- Identity:HGNC:10537
- Gene:SARS1
- Long gene name:seryl-tRNA synthetase 1
- Synonyms gene name:seryl-tRNA synthetase
- Synonyms:SERS
- Discovery year:1995-06-09
- Entrez gene record:6301
- Pubmed identification:9431993
- RefSeq identity:NM_006513
- Classification:Aminoacyl tRNA synthetases, Class II
- VEGA ID:OTTHUMG00000011726
- Identity:HGNC:17697
- Gene:SARS2
- Long gene name:seryl-tRNA synthetase 2, mitochondrial
- Synonyms gene name:serine-tRNA ligase, mitochondrial, seryl-tRNA synthetase 2
- Synonyms:FLJ20450, mtSerRSSerRSmtSARSSERSSYS
- Discovery year:2002-10-09
- Entrez gene record:54938
- Pubmed identification:10764807
- RefSeq identity:NM_017827
- Classification:Aminoacyl tRNA synthetases, Class II
- VEGA ID:OTTHUMG00000182691
- Gene symbolSARS1, SARS2
- isotype filter
- Human IgG1
- kappa
- Short nameAnti-CoV-2 & SARS-CoV S1 Antibody (Clone# CR3022)
- technique filter
- Antibody
- anti-
- anti
- TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies