Anogen

Anogen-Yes Biotech Laboratories Ltd., established in 1989 and headquartered in Mississauga, Canada, is a distinguished provider of high-quality antibody-based products for research, diagnostic, and therapeutic applications. The company offers an extensive portfolio of over 300 monoclonal and polyclonal antibodies, as well as more than 60 types of ELISA kits, serving the global biotechnology, pharmaceutical, and academic research communities.

As a research-driven organization, Anogen has developed a range of proprietary products, including Abcream, a topical anti-IL-8 monoclonal antibody treatment for psoriasis, which received approval from the State Food and Drug Administration (SFDA) of China in 2001. Anogen also conducts ongoing research in key therapeutic areas, including inflammation, Alzheimer's disease, and cancer, reflecting its commitment to advancing biomedical sciences.

Anogen’s adherence to rigorous quality standards is underscored by its ISO 13485:2016 certification, ensuring the highest level of quality in every antibody and ELISA kit delivered. With an in-house cell bank containing over 1,000 hybridomas, Anogen maintains complete control over the antibody production process, providing researchers and clinical laboratories with products that meet the highest scientific and regulatory standards.

The company focuses on meeting the growing need for antibodies in proteomics, providing essential tools for both diagnostic and therapeutic applications. Its products support the development of targeted treatments for autoimmune, inflammatory, and cardiovascular diseases. With ongoing innovations in antibody development, Anogen plays a vital role in advancing medical research and improving global healthcare.

Browse Anogen Products

Aflatoxin

SKU: MO-M40025A-01|Size: 0.1 mg

Albumin

SKU: MO-M40036-01|Size: 0.1 mg

Alpha 1-Antichymotrypsin (a1-ACT)

SKU: MO-M40098A-01|Size: 0.1 mg

Alpha 1-Antitrypsin (AAT)

SKU: MO-M40096A-01|Size: 0.1 mg

Alpha Fetoprotein

SKU: MO-T40007A-01|Size: 0.1 mg

Alpha Fetoprotein (AFP)

SKU: EL10049|Size: 96 Well

Alpha Fetoprotein (AFP) (*HRP Labeled)

SKU: MO-T40007T|Size: 0.2 mL

Alpha-Synuclein

SKU: MO-M40097A-01|Size: 0.1 mg

Amyloid Beta peptide 42

SKU: AI90001-01|Size: 0.1 mg

Amyloid Beta peptide 43

SKU: AI90002-01|Size: 0.1 mg

Amyloid beta Peptide 42 (Aβ42)

SKU: EL10057|Size: 96 Well

B Cell lymphoma factor 2 (BCL-2)

SKU: AI70003A-01|Size: 0.1 mg

Basic Fibroblast Growth Factor (b-FGF)

SKU: EL10048|Size: 96 Well

Benign Prostatic Hyperplasia (BPH)

SKU: MO-T40008A-01|Size: 0.1 mg

Beta 2 Microglobulin (*HRP Labeled)

SKU: MO-M40021T|Size: 0.2 mL

Beta 2 Microglobulin (B2MG)

SKU: MO-M40021B-01|Size: 0.1 mg

Beta amyloid peptide 40 (Aβ40) (**Biotin Labeled)

SKU: MO-M40095TB|Size: 0.1 mL

Beta amyloid peptide 40 (Aβ40) C-terminal

SKU: MO-M40095A-01|Size: 0.1 mg

Beta amyloid peptide 42 (Aβ42) (**Biotin Labeled)

SKU: MO-M40093TB|Size: 0.1 mL

Beta amyloid peptide 42 (Aβ42) C-terminal

SKU: MO-M40093A-01|Size: 0.1 mg

Beta amyloid peptide N-terminal

SKU: MO-M40094A-01|Size: 0.1 mg

Beta2-Microglobulin (B2MG)

SKU: EL10051|Size: 96 Well

C Reactive Protein (CRP)

SKU: MO-M40023A-01|Size: 0.1 mg

C Reactive Protein (CRP) polyclonal (*HRP Labeled)

SKU: AI20009P|Size: 0.2 mL

C-C Chemokine Receptor 1 (CCR1)

SKU: MO-C40005A-01|Size: 0.1 mg

CAMP response element-binding protein (CREB) [p-S133]

SKU: MO-P40003A-01|Size: 0.1 mg

CAR-T Cell Therapy Cytokines (IL-1β, IL-6, IL-8, IL-10, IL-15, GM-CSF, IFN-γ, and MCAF/MCP-1)

SKU: EM10004|Size: 96 Well

CD44

SKU: MO-L40046A-01|Size: 0.1 mg

CD47

SKU: MO-L40045A-01|Size: 0.1 mg

Cancer antigen 125 (CA125)

SKU: MO-T40012A-01|Size: 0.1 mg

Cancer antigen 50 (CA50)

SKU: MO-T40014A-01|Size: 0.1 mg

Carbohydrate antigen 19-9 (CA 19-9)

SKU: MO-T40015A-01|Size: 0.1 mg

Carcinoembryonic Antigen (CEA)

SKU: MO-T40051A-01|Size: 0.1 mg

Carcinoembryonic Antigen (CEA) (*HRP Labeled)

SKU: MO-T40051T|Size: 0.2 mL

Chorionic Gonadotropin (hCG)

SKU: AP30002|Size: 10 mg

Chorionic Gonadotropin alpha subunit (hCG-α)

SKU: MO-M40010A-01|Size: 0.1 mg

Colorectal Carcinoma

SKU: MO-T40022-01|Size: 0.1 mg

Colorectal Carcinoma/CD3 (Bi-specific)

SKU: MO-T40035-01|Size: 0.1 mg

Cytosolic K+ Channel-interacting Protein 1 (Kchip1)

SKU: AI80007-01|Size: 0.1 mg

ELISA Coating (EC) Stabilizer (5 x concentration)

SKU: S7001|Size: 500 mL

ETS-like transcription factor 1 (ELK-1) [pS383]

SKU: MO-P40002A-01|Size: 0.1 mg

Epidermal Growth Factor (EGF)

SKU: EL10010|Size: 96 Well

Epidermal Growth Factor (EGF) (**Biotin Labeled)

SKU: MO-C40044TB|Size: 0.1 mL

Epidermal Growth Factor (EGF) (*HRP Labeled)

SKU: MO-C40044T|Size: 0.2 mL

Erythropoietin (EPO)

SKU: MO-C40047A-01|Size: 0.1 mg

Factor IX

SKU: MO-M40037-01|Size: 0.1 mg

Factor X

SKU: MO-M40039-01|Size: 0.1 mg

Fibrinogen

SKU: AI80002-01|Size: 0.1 mg

Fibroblast Growth Factor - Basic (bFGF)

SKU: MO-C40046A-01|Size: 0.1 mg

Follicle Stimulating Hormone (FSH)

SKU: EL10013|Size: 96 Well

Formyl Peptide Receptor Like 1 (FPRL-1) [2nd extracellular loop

SKU: AI70001A-01|Size: 0.1 mg

Formyl Peptide Receptor Like 1 (FPRL-1) [C-terminal]

SKU: AI70001B-01|Size: 0.1 mg

Formyl Peptide Receptor-like 1 C-terminal (FPRL-1)

SKU: MO-P40006A-01|Size: 0.1 mg

Formyl Peptide Receptor-like 1 C-terminal (FPRL-1) 2nd extracellular loop

SKU: MO-P40007A-01|Size: 0.1 mg

Glutathione-S-Transferase (GST)

SKU: AI80014-01|Size: 0.1 mg

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)

SKU: MEC1004|Size: 96 Well

Granulocyte Macrophage- Colony Stimulating Factor (GM-CSF)

SKU: EL10020|Size: 96 Well

Granulocyte Macrophage- Colony Stimulating Factor (GM-CSF) Matched Antibody Pair for ELISpot

SKU: SL10020A|Size: 5x 96 Well

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF)

SKU: MO-C40090A-01|Size: 0.1 mg

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) (**Biotin Labeled)

SKU: MO-C40090TB|Size: 0.1 mL

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) (*HRP Labeled)

SKU: MO-C40090T|Size: 0.2 mL

Granulocyte-Colony Stimulating Factor Receptor (G-CSFR)

SKU: MO-C40045A-01|Size: 0.1 mg

Growth Hormone (hGH)

SKU: MO-M40012A-01|Size: 0.1 mg

Growth Hormone (hGH) (**Biotin Labeled)

SKU: MO-M40012TB|Size: 0.1 mL

Growth Hormone (hGH) (*HRP Labeled)

SKU: MO-M40012T|Size: 0.2 mL

H. pylori (HP) cytotoxin associated gene A protein (CagA)

SKU: MO-I40020A-01|Size: 0.1 mg

HAMA

SKU: EL10036|Size: 96 Well

Hepatitis B virus Surface Antigen (HBsAg)

SKU: MO-I40013A-01|Size: 0.1 mg

Hepatitis C Virus (HCV)

SKU: AI20006P|Size: 1 mg

Hepatitis C Virus (HCV) Core Protein

SKU: MO-I40015A-01|Size: 0.1 mg

Hepatitis C Virus (HCV) NS-4

SKU: MO-I40016B-01|Size: 0.1 mg

Hepatitis C Virus (HCV) non-structural protein NS-3

SKU: MO-I40018A-01|Size: 0.1 mg

Hepatitis E Virus (HEV)

SKU: MO-I40019B-01|Size: 0.1 mg

Hepatocellular Carcinoma

SKU: MO-T40006A-01|Size: 0.1 mg

High Sensitivity C Reactive Protein (CRP)

SKU: EL10022HS|Size: 96 Well

High Sensitivity Growth Hormone (H-hGH)

SKU: EL10030H|Size: 96 Well

His tag

SKU: MO-H40005B-01|Size: 0.1 mg

Human HLA-ABC (Class I HLA Heavy Chain)

SKU: MO-L40033-01|Size: 0.1 mg

Human IgA

SKU: AI80004|Size: 0.5 mg

Human IgG

SKU: AI20001Fc|Size: 1 mg

Human IgG (Fc)

SKU: AI20001P|Size: 1.0 mL

Human IgM

SKU: AI80005|Size: 0.5 mg

Human Immunodeficiency Virus-1 (HIV-1) P24 (core protein)

SKU: MO-I40002A-01|Size: 0.1 mg

Human Immunoglobulin G (IgG)

SKU: IG30001|Size: 10 mg

Human cluster of differentiation 11 alpha chain (CD11a/LFA-1)

SKU: MO-L40028-01|Size: 0.1 mg

Human cluster of differentiation 3 (CD3) antigen

SKU: MO-L40001A-01|Size: 0.1 mg

Human cluster of differentiation 71 (CD71) / Transferrin receptor

SKU: MO-L40042-01|Size: 0.1 mg

Immunodeficiency Virus-1 (HIV-1) [P24 Core Protein]

SKU: AI20008P|Size: 1 mg

Immunodeficiency Virus-1 (HIV-1) p24 (*HRP Labeled)

SKU: MO-I40002T2|Size: 0.2 mL

Immunoglobulin (Ig) Kappa (K) light Chain

SKU: MO-M40020-01|Size: 0.1 mg

Inflammatory Cytokine (IL-1α, IL-1β, IL-6, IL-8, GM-CSF, IFN-γ, MCAF and TNF-α)

SKU: EM10001|Size: 96 Well

Interferon Gamma (IFN-γ)

SKU: MO-C40004D-01|Size: 0.1 mg

Interferon-Gamma (IFN-y) Matched Antibody Pair for ELISpot

SKU: SL10024A|Size: 5x 96 Well

Interferon-Gamma (IFN-γ)

SKU: EL10024|Size: 96 Well

Interleukin-1 Beta (IL-1β)

SKU: MO-C40029A-01|Size: 0.1 mg

Interleukin-1 alpha (IL-1α)

SKU: EL10040|Size: 96 Well

Interleukin-1 beta (IL-1β)

SKU: EL10028|Size: 96 Well

Interleukin-10 (IL-10)

SKU: EL10027|Size: 96 Well

Interleukin-11 (IL-11)

SKU: EL10042|Size: 96 Well

Interleukin-12 (IL-12) (P70)

SKU: EL10032|Size: 96 Well

Advanced Immunoassay Solutions from Anogen-Yes Biotech Laboratories :

Anogen-Yes Biotech Laboratories Ltd. provides cutting-edge immunoassay kits and antibodies tailored for high-precision research in immunology, cellular biology, and related fields. These products, developed with over 30 years of expertise, support the detection and quantification of critical biomarkers such as cytokines and growth factors. With a strong foundation in antibody-based technology, Anogen ensures robust, reliable solutions that empower scientists across various domains, including biomedical research and diagnostics. Key products include: 1.Multiplex Human Cytokine ELISA Kit 2.Cytokine-related Antibodies 3.ELISA Kits for Human Cytokines and Growth Factors 4.Matched Antibody Pairs for Enhanced Detection

1.Multiplex Human Cytokine ELISA Kit :

The Multiplex Human Cytokine ELISA Kit enables the simultaneous quantification of multiple cytokines in human biological samples. It provides a high-throughput platform for precise analysis of cytokine profiles, making it ideal for immune response regulation, disease mechanism studies, and therapeutic monitoring in fields such as inflammation, oncology, and autoimmune research.

2.Cytokine-related Antibodies :

Cytokine-related Antibodies are developed to provide high specificity and affinity for human cytokines. Validated through methods like Western blotting, immunohistochemistry, and flow cytometry, they are essential tools for studying immune system dynamics, inflammatory responses, and cell signaling pathways across various research models and clinical applications.

3.ELISA Kits for Human Cytokines and Growth Factors :

ELISA Kits for Human Cytokines and Growth Factors offer high-sensitivity and reproducibility for quantifying cytokines and growth factors in human samples. These kits are key for research into immune responses, tissue growth, and disease progression, especially in cancer immunology, neurological disorders, and metabolic diseases.

4.Matched Antibody Pairs to Human Cytokines and Growth Factors :

Matched Antibody Pairs to Human Cytokines and Growth Factors are selected for optimal sensitivity and specificity in sandwich ELISA assays. These pairs are essential for quantifying cytokines and growth factors involved in immune modulation and disease pathogenesis, providing valuable insights into immune and metabolic networks in both basic and applied research.

Recent Breakthroughs

Uncovering adulteration and quality variations in commercial lavender essential oils from the Egyptian market using GC-MS and chemometrics.

Abouelela MB, El-Taher EM, Shawky EM, Baky MH.

Sci Rep

PMID:42000791

Free PMC article

Lavender (Lavandula L. spp., Lamiaceae) essential oil is widely valued for its therapeutic effects and aromatic properties. Owing to the growing global demand for this essential oil, the implementation of standardized quality assessment protocol is essential to ensure its quality. This study aimed to perform a comparative metabolite profiling of four commercially available lavender oils in the Egyptian market using Gas chromatography-mass spectrometry (GC-MS) analysis combined with chemometric analysis. A total of 54 volatile metabolites were identified belonging to 8 chemical classes including alcohols, aldehyde/ketone, esters, fatty acids/esters, oxides, aliphatic, monoterpene, and sesquiterpene hydrocarbons. Alcohols and esters represented the abundant classes accounting for 24.7-42.6% and 11.4-46.1%, respectively, of the total volatile composition. Linalool and linalyl acetate, the principal quality markers of lavender oil were comparatively higher in L-Sha (33.61, and 24.72%) and L-Rag (46.09, and 32.65%), indicating their higher quality among the examined samples. In contrast, certain samples exhibited unusually high levels of non-characteristic fatty acid esters and synthetic glycols, suggesting possible dilution or adulteration with carrier oils or formulation additives. Multivariate analysis further demonstrated clear compositional discrimination among samples, confirming substantial variability in the quality of commercial lavender oils available in the Egyptian market. These findings highlight the importance of GC-MS profiling combined with chemometric analysis as a robust tool for authenticity verification, quality control, and detection of potential adulteration in commercial essential oil products.

Untargeted urinary metabolomics reveals metabolic alterations and severity biomarkers in cardiac surgery-associated acute kidney injury.

Lee CC, Hsieh YJ, Chang CH, Yu JS, Chen KH, Hung CC, Chen SW, Tu WJ, Chen YT.

Metabolomics

PMID:41999450

Free PMC article

Introduction Cardiac surgery-associated acute kidney injury (CS-AKI) is a frequent, serious complication linked to increased morbidity, mortality, and long-term kidney dysfunction. Progress in early detection and effective interventions remains limited, underscoring the need for novel biomarkers and therapeutic targets. Given the kidneys' high metabolic activity, metabolomics offers a powerful strategy to identify such markers and provide mechanistic insights. Objectives Our goal is to investigate urinary metabolome alterations associated with CS-AKI. Methods We performed untargeted amine/phenol metabolomic profiling of urine samples collected within four hours post-surgery from 55 cardiac surgery patients (26 non-AKI, 29 AKI), using high-performance chemical isotope labeling and liquid chromatography-mass spectrometry (LC-MS). Multivariate analyses were applied to assess group separation and to evaluate the diagnostic performance of key metabolites. Results Urinary metabolomic profiles were significantly different between AKI and non-AKI patients. Of 1384 detected metabolites, 45 were differentially altered in AKI (defined by a fold change exceeding the mean ± 2 standard deviations, raw p 2 fold change = 1.95, raw p Conclusions Untargeted urinary metabolomics distinguished AKI from non-AKI after cardiac surgery and identified distinct metabolic signatures associated with AKI severity. This work underscores the value of urinary metabolomics for revealing mechanistic pathways and identifying candidate biomarkers that may aid early diagnosis and monitoring of CS-AKI.

Linking metabolism and metastasis: elevated α-hydroxybutyric acid in oral squamous cell carcinoma patients with lymph node metastasis.

Gu X, Coates PJ, Wang L, Sgaramella N, Magan M, Nylander K.

Metabolomics

PMID:41999538

Free PMC article

Introduction Metabolic reprogramming is a hallmark of cancer. Plasma metabolomics offers a minimally invasive approach for identifying metabolic alterations that may provide insights into tumor progression. Objectives We aimed to characterize plasma metabolomic profiles in patients with oral squamous cell carcinoma (OSCC) and evaluate their clinical relevance. Methods Plasma samples from 43 OSCC patients and 129 cancer-free controls, matched at a 1:3 ratio based on age, sex, and body mass index, were analyzed using gas chromatography-mass spectrometry (GC-MS). A random forest algorithm was applied to identify key metabolic features distinguishing OSCC from controls. The clinical significance of the top metabolites was assessed and validated in another OSCC cohort (n = 27). Results A total of 113 compounds were putatively annotated and analyzed based on relative abundances. A ten-feature panel demonstrated good classification performance (area under the curve = 0.87; Matthews correlation coefficient = 0.703). The ten features are maltose, glucose, xylulose, δ-gluconolactone, fructose, indoleacetic acid, α-hydroxybutyric acid, glutamic acid, cysteine, and the monoacylglyceride MG(18:1(9Z)/0:0/0:0), suggesting dysregulated carbohydrate metabolism and oxidative stress as the major plasma metabolomic alterations in OSCC. Notably, α-hydroxybutyric acid levels were elevated in patients with regional lymph node metastasis compared with those without. Conclusion Our findings underscore the intricate interplay between altered glucose metabolism, redox imbalance, and OSCC. α-hydroxybutyric acid, a marker of oxidative stress and an indicator of insulin resistance, may be associated with metastatic progression.

Insect-resistant soybean genotypes accumulate rutin and its O-methylated derivative narcissin, a more potent flavonol targeting Anticarsia gemmatalis digestive and detoxification enzymes and reducing larval survival.

de Assis JN, Pinheiro VJM, Varejão JOS, Pinto IPA, Lourenção AL, Oliveira NS, Moraes GCM, Varejão EVV, Almeida Oliveira MG, de Oliveira Ramos HJ.

J Sci Food Agric

PMID:41999131

Free PMC article

Background Soybean underpins Brazil's agricultural, yet its sustainability is threatened by lepidopteran pests such as Anticarsia gemmatalis. Although insect-resistant cultivars have long been associated with the constitutive accumulation of quercetin-derived flavonols, the biochemical mechanisms underlying this resistance remain poorly understood. In particular, the role of flavonol O-methylation in enhancing plant defense has not been demonstrated. Results Here we combined metabolite identification, biological assays, and structure-based modeling to investigate flavonol-mediated resistance in soybean. The resistant genotype IAC 17 was found to accumulate not only rutin (quercetin 3-O-rutinoside; [M + H] + = 611 Da) but also its O-methylated derivative isorhamnetin 3-O-rutinoside (narcissin; [M + H] + = 625 Da). The 625 Da compound was purified by reversed-phase high-performance liquid chromatography and structurally confirmed by liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance analyses. Chemical methylation of rutin using methyl iodide generated methylated derivatives that were evaluated in dietary bioassays with A. gemmatalis larvae. Both rutin and its methylated derivatives reduced survival, but O-methylation markedly enhanced toxicity: methylated rutin caused approximately 95% mortality within 5 days, whereas non-methylated rutin required about 17 days to reach comparable lethality. Molecular docking against the 70 most abundant larval midgut proteins revealed strong binding of both flavonols to proteases, cytochrome P450 enzymes, glutathione S-transferases, and membrane-associated proteins. Conclusion These findings support a dual-ligand model in which rutin and narcissin cooperatively disrupt digestive and detoxification pathways in the insect midgut. The discovery of a constitutive flavonol O-methylation branch identifies narcissin as a potent defensive metabolite and provides mechanistic targets for breeding and metabolic engineering strategies aimed at developing soybean cultivars with improved resistance. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

One-Step Chemiluminescent Immunoassay for the Key Synthesis Protein of Ochratoxin A Using a Shark Single-Domain Antibody-Alkaline Phosphatase Fusion Protein.

Wang Z, He Z, Xie X, Yang Q, Huang D, Sun Z, Liu X.

Anal Chem

PMID:41999309

Free PMC article

Basic leucine zipper (BZIP) proteins constitute one of the largest and most diverse families of transcription factors and play a crucial role in OTA biosynthesis by regulating the expression of genes within the biosynthetic gene cluster. As a key regulatory protein, BZIP holds promise as an early biomarker for identifying OTA-producing fungi before toxin accumulation occurs, thereby helping to prevent contaminated products from entering the food supply chain. Despite its potential significance, there have been no comprehensive reports describing the development of BZIP-specific antibodies. Herein, we generated a variable new antigen receptor-alkaline phosphatase (VNAR-ALP) fusion and developed a VNAR-ALP fusion-based chemiluminescent immunoassay (VACLIA) for BZIP detection. The optimized VACLIA exhibits a limit of detection of 0.058 μg/mL and a linear range of 0.3125-5 μg/mL, along with good selectivity. Recovery experiments conducted using spiked maize and coffee samples at different BZIP concentrations demonstrated high accuracy and reliability, with recoveries ranging from 102.50% to 111.39% and relative standard deviations not exceeding 12%. The detection of actual maize samples using liquid chromatography-tandem mass spectrometry showed a strong correlation with the results obtained from VACLIA, further validating the assay's effectiveness in real sample analysis. A comparative analysis of VACLIA with other global food safety monitoring systems highlighted its unique capability to identify potential hazards, provide timely alerts, and effectively mitigate OTA risk in food products. Overall, the developed VACLIA exhibited robust performance, high selectivity, and broad applicability in the detection of real samples, demonstrating its potential as a valuable tool for food safety monitoring.