F12, Coagulation factor XII
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Catalog numberIMS01-137-306
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Price:
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Size100 µl (15.1 mg/ml)
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Available ordering formatLiquid in 0.9% NaCl, 0.1% sodium azide
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Immunogenpurified full length native protein P00748
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Raised inHen
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ClonalityPolyclonal
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ClonePolyclonal
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PurificationTotal IgY fraction
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How to reconstituteSee included datasheet or contact our support service
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Storage conditionstore at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
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Verified applicationsELISA (ELISA)
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Connected productsIMS01-118-307 | anti-Coagulation factor VIIAS00 001 | anti-Coagulation factor VIIaIMS01-015-308 | anti-Coagulation factor VIIIAS05 058 | anti-Coagulation factor IXSecondary antibodies
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Recommended dilutions for use1: 10 000 (ELISA)
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Molecular weight expected аpparent67 kDa
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Verified reactivityhuman
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Possible reactivityhuman
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No reactivityno confirmed exceptions from predicted reactivity known in the moment
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Supplementary informationdetects human coagulation factor XII and XIIa
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Referencesto be added when available
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Scientific contextCoagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any apparent clinical symptoms and the sole effect is that whole blood clotting time is prolonged.
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NotesNone
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Protein numberP00748
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TAIR numberRefer to NCBI
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DescriptionAplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
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Gene target
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Gene symbolF12, SIGLEC12
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Short nameF12, Coagulation factor XII
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Alternative nameF12, Coagulation factor XII
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Gene info
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Identity
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Gene
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Long gene namecoagulation factor XII
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Synonyms gene name
- coagulation factor XII (Hageman factor)
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namesialic acid binding Ig like lectin 12
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Synonyms gene
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Synonyms gene name
- SIGLEC-like 1
- sialic acid binding Ig-like lectin 12
- sialic acid binding Ig-like lectin 12 (gene/pseudogene)
- sialic acid binding Ig like lectin 12 (gene/pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-08-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C2-set domain containing
- I-set domain containing
- Sialic acid binding Ig like lectins
- V-set domain containing
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VEGA ID