ADAM 17, CT (ADAM17, A Disintegrin and Metalloproteinase Domain 17 (Tumor Necrosis Factor, alpha, Converting Enzyme), CSVP, TACE, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM Metallopeptidase Domain 17, TNF-alpha Converting Enzyme, A Disintegrin and Met[ADAM 17]

• Catalog number
  MBS659587
• Price
  Please ask
• Size
  NA

• Products_type
  Peptide
• Description
  The ADAM 17, CT (ADAM17, A Disintegrin Metalloproteinase Domain 17 (Tumor Necrosis Factor, alpha, Converting Enzyme), CSVP, TACE, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM Metallopeptidase Domain 17, TNF-alpha Converting Enzyme, A Disintegrin Met[ADAM 17] is a α- or alpha protein sometimes glycoprotein present in blood. Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

• Gene target
  ADAM   ADAM17   Disintegrin   Metalloproteinase   Domain   Tumor   Necrosis   Factor   alpha   Converting   CSVP   TACE   cSVP   CD156b   CD156b   MGC71942   TACE   cSVPADAM   Metallopeptidase   Domain   TNF-alpha   Converting   Disintegrin   Met[ADAM   17]  
• Gene symbol
  ADAM17, TNF, TNFRSF1A, ADAMTS10, ADAMTS6, TNFRSF1B, ADAMTS8, ADAMTS7, ADAMTS2, LTBR
• Short name
  ADAM 17, CT (ADAM17, A Disintegrin Metalloproteinase Domain 17 (Tumor Necrosis Factor, alpha, Converting Enzyme), CSVP, TACE, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM Metallopeptidase Domain 17, TNF-alpha Converting Enzyme, A Disintegrin Met[ADAM 17]
• Technique
  Enzyme, enzymes
• Alternative name
  ADAM 17, CT (ADAM metallopeptidase domain 17, A Disintegrin and Metalloproteinase Domain 17 (Tumor Necrosis Factor, a, Converting Enzyme), CSVP, TACE, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM Metallopeptidase Domain 17, tumor necrosis factor-a Converting Enzyme, A Disintegrin and Met[ADAM 17]
• Alternative technique
  enzymes
• Alternative to gene target
  ADAM metallopeptidase domain 17, ADAM18 and CD156B and CSVP and NISBD and TACE, ADAM17 and IDBG-27788 and ENSG00000151694 and 6868, PDZ domain binding, Cell surfaces, Adam17 and IDBG-130508 and ENSMUSG00000052593 and 11491, ADAM17 and IDBG-638333 and ENSBTAG00000001141 and 517541
• Tissue
  tumor

Gene info

• Identity
  HGNC:195
• Gene
  ADAM17
• Long gene name
  ADAM metallopeptidase domain 17
• Synonyms gene
  • TACE
• Synonyms gene name
  • tumor necrosis factor, alpha, converting enzyme
• Synonyms
  • cSVP
  • CD156B
• Synonyms name
  • cartilage snake venom-like protease
  • TNF-alpha convertase enzyme
  • a disintegrin and metalloproteinase 17
• GenBank acession
  • U69611
• Locus
  2p25.1
• Discovery year
  1997-04-10
• Entrez gene record
  6868
• Pubmed identfication
  • 9034190
  • 9574564
• Classification
  • ADAM metallopeptidase domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000090425
• Locus Specific Databases
  • LRG_1203

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:13201
• Gene
  ADAMTS10
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 10
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
• Synonyms
  • ADAM-TS10
• GenBank acession
  • AF163762
• Locus
  19p13.2
• Discovery year
  2001-04-05
• Entrez gene record
  81794
• Pubmed identfication
  • 15355968
  • 15368195
• RefSeq identity
  • NM_030957
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000182216

Gene info

• Identity
  HGNC:222
• Gene
  ADAMTS6
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 6
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6
• Synonyms
  • ADAM-TS6
• Synonyms name
  • a disintegrin and metalloproteinase with thrombospondin motifs 6
• GenBank acession
  • AF140674
• Locus
  5q12.3
• Discovery year
  1999-09-06
• Entrez gene record
  11174
• Pubmed identfication
  • 10464288
• RefSeq identity
  • NM_197941
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000074079

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:224
• Gene
  ADAMTS8
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 8
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
• Synonyms
  • METH2
  • FLJ41712
  • ADAM-TS8
• GenBank acession
  • AF060153
• Locus
  11q24.3
• Discovery year
  1999-08-23
• Entrez gene record
  11095
• Pubmed identfication
  • 10438512
• RefSeq identity
  • NM_007037
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000165656

Gene info

• Identity
  HGNC:223
• Gene
  ADAMTS7
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 7
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7
• Synonyms
  • ADAM-TS7
  • DKFZp434H204
• Synonyms name
  • COMPase
  • a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein
• GenBank acession
  • AF140675
• Locus
  15q25.1
• Discovery year
  1999-09-06
• Entrez gene record
  11173
• Pubmed identfication
  • 10464288
• RefSeq identity
  • NM_014272
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000172907

Gene info

• Identity
  HGNC:218
• Gene
  ADAMTS2
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 2
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
• Synonyms
  • ADAMTS-3
  • hPCPNI
  • PCINP
  • ADAM-TS2
  • NPI
• Synonyms name
  • procollagen I N-proteinase
  • procollagen N-endopeptidase
• GenBank acession
  • AJ003125
• Locus
  5q35.3
• Discovery year
  1999-04-15
• Entrez gene record
  9509
• Pubmed identfication
  • 10094461
  • 15373769
• RefSeq identity
  • NM_014244
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000130915

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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