Human CD45 / PTPRC Protein, Llama IgG2b Fc Tag, low endotoxin

• Background:

  CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

• Description:

  Human CD45 Protein, Llama IgG2b Fc Tag (CD5-H5259) is expressed from human 293 cells (HEK293) . It contains AA Gln 26 - Lys 577 (Accession # P08575-3) .

• Specifications:

  This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 88.6 kDa. The protein migrates as 200-250 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  P08575-3

• Expression Region:

  Gln 26 - Lys 577

• Host:

  HEK293

• Target:

  CD45

• Conjugation:

  Unconjugated

• Tag:

  C-LlamaFc (LlamaIgG2b)

• Source:

  Human

• Stability:

  ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Endotoxin:

  0.05 EU per μg

• Purity:

  90%

• Format:

  Powder

• Buffer:

  50 mM Tris, 200 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5

• Additives:

  Trehalose

• Molecular Weight:

  88.6 kDa

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  100ug*1

• Species:

  Human