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Recombinant Mouse NKG2D Ligand 1 NKG2DL ULBP1 Protein C 6His

Recombinant Mouse NKG2D Ligand 1 NKG2DL ULBP1 Protein C 6His is available 2 times from Elabscience labs

PKSM041116-10µg | Recombinant Mouse NKG2D Ligand 1/NKG2DL/ULBP1 Protein(C-6His) size: 10µg | 243.32 USD

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PKSM041116-50µg | Recombinant Mouse NKG2D Ligand 1/NKG2DL/ULBP1 Protein(C-6His) 50µg size: 50µg | 450.67 USD

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Synonym ULBP1; RAET1I; NKG2DL1
Activity NA
Sequence Pro26-Thr211
Fusion tag C-6His
Accession Q8HWA3
Expressed Host Human Cells
Shipping The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Purity >95% as determined by reducing SDS-PAGE.
Stability and Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
Mol Mass 22.3 kDa
AP Mol Mass 30-40kDa
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Background Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. It can activate multiple signaling pathways in primary NK cells, gamma delta T cells, and CD8+ alpha beta T cells, resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart, brain, lung, liver, bone marrow and some tumor cells, T-cells, B-cells, As an unconventional member of the MHC class I family, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
Description FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Test Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name Mus musculus
Source Recombinants or rec. proteins
Group recombinants
Technique Recombinant, Mouse
Host mouse
Species Mouse
Alternative technique rec
Alternative to gene target UL16 binding protein 1, ULBP1 and IDBG-97845 and ENSG00000111981 and 80329, natural killer cell lectin-like receptor binding, Plasma membranes
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Recombinant Mouse NKG2D Ligand 1 NKG2DL ULBP1 Protein C 6His
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • NKG2D
  • Ligand
  • 1/NKG2DL/ULBP1
  • Protein(C-6His
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